The DNA sensors AIM2 and IFI16 are NET-binding SLE autoantigens
B. Antiochos, P. Fenaroli, A. Rosenberg, A. Baer, J. Sohn, J. Li, M. Petri, D. W. Goldman, C. Mecoli, L. Casciola-Rosen, A. Rosen
The paper identifies AIM2 and IFI16 as autoantigens in SLE that bind NETs, leading to DNase-resistant structures that promote sustained IFN signaling.
bioRxiv · Aug 19, 2021Immunology