J. Li

Graph-based modeling of multiparametric MRI deciphers molecular states of high-grade glioma invasion with prognostic implications

This paper uses graph-based modeling of multiparametric MRI to identify molecular states in high-grade glioma and shows their prognostic significance.

Overventilation-induced airspace acidification increases susceptibility to Pseudomonas pneumonia

This study shows that high tidal volume ventilation acidifies alveolar lining fluid, increasing susceptibility to Pseudomonas pneumonia by reducing NHE1 expression.

Cholinergic interneuron control of GABAergic circuits targeting spiny projection neurons is disrupted in parkinsonian models

This study investigates how Parkinson's disease disrupts cholinergic interneuron control of GABAergic circuits in the striatum, showing reduced nicotinic AChR expression in interneurons in disease models.

A vagal gut-brain axis for feeding induced gastric secretion

The paper identifies cell-type-specific vagal and enteric circuits that control meal-induced gastric secretion and shows segregation of secretory and motor functions.

Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing

This paper introduces DRAM, a method for transcriptome-wide m5C detection using deaminase and reader proteins, showing high overlap with BS-seq data and supporting low-input RNA.

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

CDK8/19 Inhibition Attenuates G1 Arrest Induced by BCR-ABL Antagonists and Accelerates Death of Chronic Myelogenous Leukemia Cells

This study shows that CDK8/19 inhibition overcomes BCR-ABL inhibitor-induced G1 arrest and promotes apoptosis in CML cells.

Biologically-informed deep neural networks provide quantitative assessment of intratumoral heterogeneity in post-treatment glioblastoma

This paper develops BioNet, a biologically-informed deep learning model, to predict intratumoral heterogeneity in post-treatment glioblastoma using MRI and biopsy data, showing improved performance over existing methods.

SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1

This study identifies GLUT1 as a target of SSRIs, showing citalopram inhibits HCC by reversing the Warburg effect through GLUT1 antagonism.

Multimodal mechano-microscopy reveals mechanical phenotypes of breast cancer spheroids in three dimensions

This study uses multimodal mechano-microscopy to analyze mechanical properties of breast cancer spheroids in 3D environments, revealing differences in elasticity and invasion behavior between non-metastatic and metastatic spheroids.

MYC and p53 alterations cooperate through VEGF signaling to repress cytotoxic T cell and immunotherapy responses in prostate cancer

This study shows that MYC and p53 alterations in prostate cancer cooperate via VEGF signaling to suppress T cell activity and immunotherapy responses, and that targeting VEGFR2 can enhance immunotherapy efficacy.

PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

This study identifies PA28γ's role in promoting oral squamous cell carcinoma progression by enhancing mitochondrial function through interaction with C1QBP.

Super-enhancer-driven CACNA2D2 is an EWSR1::WT1 signature gene encoding a diagnostic marker for desmoplastic small round cell tumor (DSRCT)

The paper identifies CACNA2D2 as a super-enhancer-driven target of EWSR1::WT1 and demonstrates its utility as a diagnostic biomarker for DSRCT.

FLASH radiotherapy using high-energy X-rays: validation of the FLASH effect triggered by a compact single high-energy X-ray source device

This study validates the FLASH effect using a compact high-energy X-ray source in mice, showing protective effects on normal tissues but no significant tumor response differences between FLASH and conventional radiotherapy.

Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer

This study shows that ongoing whole-genome doubling in ovarian cancer promotes cell diversity and immune dysregulation through chromosomal instability and quiescent states.

T3SS translocon induces pyroptosis by direct interaction with NLRC4/NAIP inflammasome

This study identifies EseB, a T3SS translocon protein, as a direct activator of the NLRC4/NAIP inflammasome, inducing pyroptosis in host cells through a conserved mechanism across T3SS-positive bacteria.

Adipokinetic hormone signaling mediates the enhanced fecundity of Diaphorina citri infected by 'Candidatus Liberibacter asiaticus'

This study identifies adipokinetic hormone signaling as a key mediator of increased fecundity in CLas-infected D. citri, revealing a mutualistic interaction between the bacterium and the insect.

Blebs regulate phosphoinositides distribution and promote cell survival through the Septin-SH3KBP1-PI3K axis

The paper shows blebs regulate phosphoinositides distribution via the Septin-SH3KBP1-PI3K axis, promoting cell survival during anoikis resistance.

Deterministic processes played more important roles than stochastic processes in driving community assembly of ectomycorrhizal fungal associated with Pinus tabuliformis - an endemic Pinaceae species in China

The study examines EM fungal communities associated with Pinus tabuliformis, finding deterministic processes dominate community assembly over stochastic processes.

Synergically enhanced anti-tumor immunity of in vivo CAR by circRNA vaccine boosting

This study develops circRNA-based in vivo CAR and vaccines that synergistically enhance anti-tumor immunity in mice.

Identification of P-type ATPase as a bacterial transporter for host-derived small RNA

This study identifies a bacterial P-type ATPase transporter, PtaT, that specifically binds and mediates the uptake of host-derived tsRNAs in Fusobacterium nucleatum.

AI-driven high-throughput droplet screening of cell-free gene expression

This paper introduces DropAI, an AI-driven droplet-based screening method to optimize cell-free gene expression systems, achieving cost reduction and yield improvement.

Phosphodiesterase 3 inhibitors boost bone outgrowth

This study shows that PDE3 inhibitors enhance bone growth by increasing Ca2+ influx through TRPM7 channels in chondrocytes, suggesting potential repositioning for short stature syndromes.

A Drug-Elicitable Alternative-Splicing Module (DreAM) for Tunable AAV Expression and Controlled Myocardial Regeneration

Reversible ubiquitination of integrated domain controls paired NLR immune receptor complex homeostasis

The paper identifies a ubiquitination-deubiquitination cycle regulating the stability and function of the paired NLR receptor complex RRS1/RPS4 in Arabidopsis.

Predictive and Experimental Motif Interaction Analysis Identifies Functions of the WNK-OSR1/SPAK Pathway

The paper identifies interaction motifs of the WNK-OSR1/SPAK pathway and validates their function through experimental testing.

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner

This study shows that long-term NMN treatment improves healthspan and extends lifespan in female mice but not males, with sex-specific effects on metabolism and microbiome.

De Novo Design of Integrin α5β1 Modulating Proteins for Regenerative Medicine

The paper designs de novo proteins called NeoNectins that specifically bind integrin α5β1, enhancing cell attachment and tissue integration in biomaterials.

Lectins and polysaccharide EPS I have flow-responsive roles in the attachment and biofilm mechanics of plant pathogenic Ralstonia

This study shows that Ralstonia pseudosolanacearum lectins and EPS I have dual roles in biofilm attachment and mechanics depending on environmental flow conditions.

Phase-Separating Peptide Coacervates with Programmable Material Properties for Universal Intracellular Delivery of Macromolecules

This study manipulates phase-separating peptide sequences to control coacervate microdroplet properties and intracellular delivery kinetics of macromolecules.