Multimodal Analysis for Human ex vivo Studies Shows Extensive Molecular Changes from Delays in Blood Processing
A. K. Savage, M. V. Gutschow, T. Chiang, K. Henderson, R. Green, M. Chaudhari, E. Swanson, A. T. Heubeck, N. Kondza, K. C. Burley, P. C. Genge, C. Lord, T. Smith, Z. Thomson, A. Beaubien, , T. F. Bumol
This study shows that delayed blood processing causes significant changes in single-cell transcriptomes and plasma proteomes within 6 hours, potentially confounding disease-related biological variance.
bioRxiv · Oct 18, 2020Immunology