R. Green

Bispecific GD2 x B7-H3 Antibody Improves Tumor Targeting and Reduces Toxicity while Maintaining Efficacy for Neuroblastoma

Working together to control mutation: how collective peroxide detoxification determines microbial mutation rate plasticity

This study identifies hydrogen peroxide detoxification as the mechanism behind density-dependent mutation rate plasticity in microbial populations.

Comparison of concentrations of lead (Pb) in meat from wild-shot common pheasants killed using shotgun pellets principally composed of lead, iron (Fe), bismuth (Bi) and zinc (Zn)

This study compares lead concentrations in meat from pheasants shot with lead or iron pellets, finding significantly higher lead levels in those shot with lead.

A small molecule RIG-I agonist serves to adjuvant broad multifaceted influenza virus vaccine immunity

This paper identifies a small molecule RIG-I agonist, KIN1148, that enhances influenza vaccine immunity by activating non-canonical RIG-I pathways to boost both antibody and T cell responses.

Implications for food safety of the size and location of fragments of lead shotgun pellets embedded in hunted carcasses of small game animals intended for human consumption

This study examines lead pellet fragments in pheasant carcasses, finding small, undetectable lead particles that pose dietary lead exposure risks to consumers.

The inositol-requiring enzyme 1α/X-box protein 1 (IRE1α/XBP1) pathway of the unfolded protein response is impaired in pediatric cholestatic liver disease explants

This study shows that the IRE1α/XBP1 pathway is underactive in pediatric cholestatic liver disease explants compared to normal and non-cholestatic controls.

Mechanisms that ensure speed and fidelity in eukaryotic translation termination

The paper uses single-molecule fluorescence assays to study eukaryotic translation termination dynamics in yeast, revealing a conserved multi-step process involving eRF1 and eRF3.

Female immunity protects from cutaneous squamous cell carcinoma

The paper shows women are more protected from aggressive cutaneous squamous cell carcinoma due to stronger immune activation compared to men.

Multimodal Analysis for Human ex vivo Studies Shows Extensive Molecular Changes from Delays in Blood Processing

This study shows that delayed blood processing causes significant changes in single-cell transcriptomes and plasma proteomes within 6 hours, potentially confounding disease-related biological variance.

Steric Interactions at Gln154 in ZEITLUPE Induce Reorganization of the LOV Domain Dimer Interface

The paper identifies how mutations at Gly46 in ZEITLUPE cause structural changes in the LOV domain dimer interface, revealing a unique signaling mechanism.

TEA-seq: a trimodal assay for integrated single cell measurement of transcription, epitopes, and chromatin accessibility

The paper introduces TEA-seq, a trimodal assay that integrates scRNA-seq, cell surface epitopes, and scATAC-seq to improve single-cell analysis of transcription, epitopes, and chromatin accessibility.

Puromycin reactivity does not accurately localize translation at the subcellular level

The paper shows that puromycin-labeled peptides can diffuse away from ribosomes even with elongation inhibitors, leading to misleading subcellular localization of translation.

Dynamic regulation of translation quality control associated with ribosome stalling

The paper develops a SunTag-based reporter to study ribosome stalling during translation of poly(A)-containing mRNAs and finds that stalled ribosomes are slowly cleared by quality control machinery, targeting nascent proteins rather than mRNA.

Metabolic excretion associated with nutrient-growth dysregulation promotes the rapid evolution of an overt metabolic defect

The paper shows that nutrient-growth dysregulation in yeast leads to the evolution of a metabolic defect involving organosulfur release, which confers a fitness advantage under specific conditions.

The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent.

This study shows UVB exposure triggers local and systemic Type I interferon responses in mice, which are largely cGAS-dependent and contribute to disease flares in SLE.

Insights from two decades of the Student Conference on Conservation Science

This study analyzes 3,245 SCCS conference applications to show increased focus on human-nature benefits and social science integration in tropical field research by early-career conservationists.

Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts

This study identifies molecular mechanisms of translational stalling caused by inhibitory codon pairs and poly(A) tracts using in vitro biochemistry, ribosome profiling, and cryo-EM.

Human DNA-PK activates a STING-independent DNA sensing pathway

The paper identifies a STING-independent DNA sensing pathway in human cells, mediated by DNA-PK, and shows its role in antiviral responses and distinct activation from DNA damage.

Disentangling strictly self-serving mutations from win-win mutations in a mutualistic microbial community

The paper shows that a mutation increasing hypoxanthine release in yeast was mistakenly thought to be win-win but is actually self-serving due to increased cell size and lysine consumption.

Resolving challenges in quantitative modeling of microbial community dynamics

The paper identifies and resolves challenges in modeling microbial community dynamics by re-measuring strain phenotypes in community-like environments.

A positive feedback-based mechanism for constriction rate acceleration during cytokinesis in C. elegans

The paper investigates cytokinesis in C. elegans embryos, showing that positive feedback between myosin and cortical flow accelerates ring constriction rate as the ring shrinks.