Identification and targeting of microbial putrescine acetylation in bloodstream infections
J. R. Mayers, J. Varon, R. R. Zhou, M. Daniel-Ivad, C. Beaulieu, A. Bholse, N. R. Glasser, F. M. Lichtenauer, J. Ng, M. Pinilla Vera, C. Huttenhower, M. A. Perrella, C. B. Clish, S. D. Zhao, R. M. Baron, E. P. Balskus
The paper identifies bacterially-derived N-acetylputrescine as a marker of severe gram-negative bloodstream infections and shows that inhibiting its synthesis reduces bacterial growth and antibiotic resistance.
bioRxiv · Sep 21, 2023 · PreprintMicrobiology