J. Ng

Transcutaneous auricular vagus nerve stimulation enhances emotional bias towards happiness in healthy young adults: A comparative study of electrical and ultrasound stimulation

This study compares the effects of electrical and ultrasound transcutaneous auricular vagus nerve stimulation on emotional bias in healthy adults, finding both methods enhance positive emotional interpretation.

Near infrared spectroscopic characterization of sesamin, a dietary lignan natural product

This paper provides the first near infrared spectrum of sesamin and assigns vibrational modes by comparing experimental data with quantum chemical calculations.

Identification and targeting of microbial putrescine acetylation in bloodstream infections

The paper identifies bacterially-derived N-acetylputrescine as a marker of severe gram-negative bloodstream infections and shows that inhibiting its synthesis reduces bacterial growth and antibiotic resistance.

Discovery of New Broad-Spectrum Anti-Infectives for Eukaryotic Pathogens Using Bioorganometallic Chemistry

Simple derivatives of the well-known antifungal drug fluconazole were found to be highly effective in vivo against fungal infections and potent against parasitic nematodes causing lymphatic filariasis and soil-transmitted helminths.

SARS-CoV-2 variants exhibit differential gut tropism and dysbiosis in Syrian golden hamsters.

This study examines SARS-CoV-2 variants' gut tropism and impact on gut microbiota in Syrian golden hamsters, finding Delta's stronger gastrointestinal preference and greater microbial dysbiosis.

Brief report: Reclassifying SCLC-Y as SMARCA4 deficient malignancies - resolving the controversy

The paper reclassifies YAP1-expressing SCLC-Y as SMARCA4-deficient malignancies, showing they lack SCLC features and instead resemble SMARCA4-deficient tumors.

ETV2 regulates PARP-1 binding protein to induce ER stress-mediated cell death in tuberin-deficient cells

This study identifies ETV2 as a regulator of cell death in Tsc2-deficient cells through PARPBP and ER stress, suggesting a potential therapeutic target for LAM.

Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the quality of type 2 protective response

This study identifies distinct Tfh cell populations during chronic and acute helminth infections and shows their role in type 2 immune responses.

Environmental niche and demographic modeling of American chestnut near its southwestern range limit

The paper models the environmental suitability and demographic future of American chestnut in its southwestern range limit, finding suitable habitat but predicting population decline without conservation efforts.

c-Rel is required for IL-33-dependent activation of ILC2s

This study identifies c-Rel as essential for IL-33-dependent activation of ILC2s, showing its role in lung inflammation and cytokine production.

Single Cell RNA-seq and Mass Cytometry Reveals a Novel and a Targetable Population of Macrophages in Idiopathic Pulmonary Fibrosis

The paper identifies a novel, targetable macrophage population in idiopathic pulmonary fibrosis using single-cell RNA-seq, CyTOF, and flow cytometry.

Regions of Highly Recurrent Electrogram Morphology at Sites of Low Cycle Length Accurately Reflect Arrhythmogenic Substrate for Atrial Fibrillation - Implications For a New, Mechanism Guided Therapeutic Approach for Atrial Fibrillation

This study identifies electrogram morphology recurrence as a marker of arrhythmogenic substrate in atrial fibrillation, suggesting it could guide targeted ablation therapy.

Single-cell transcriptomic analyses define distinct peripheral B cell subsets and discrete development pathways

The paper uses single-cell transcriptomics to identify distinct B cell subsets and developmental pathways in peripheral blood.

Immunoreactive peptide maps of SARS-CoV-2 and other human coronaviruses

The paper identifies humoral immune responses to SARS-CoV-2 and other human coronaviruses peptides to detect infections and discover immunity biomarkers.

The methyltransferase DOT1L limits activation and the Th1 program in CD4+ T cells during infection and inflammation

This study shows that DOT1L limits Th1 activation and lineage stability in CD4+ T cells, with implications for immune response regulation.

Rubisco activase remodels plant Rubisco via the large subunit N-terminus

This study identifies the N-terminus of the Rubisco large subunit as critical for Rca activation, showing mutations impair activation but increase carboxylation rates.

A Comprehensive Assessment of Human Natural Killer Cell Phenotype and Function in Whole Blood

This paper evaluates NK cell phenotype and function in whole blood versus cryopreserved PBMCs, finding significant differences in receptor expression.

Disruption of NOX2-dependent Oxidative Injury with a Targeted Gene-Therapy Approach Prevents Atrial Fibrillation in a Canine Model

This study shows that disrupting NOX2-dependent oxidative injury with gene therapy prevents atrial fibrillation in dogs.

Reproduction and longevity A Mendelian randomization study of gonadotropin-releasing hormone and ischemic heart disease

This study uses Mendelian randomization to investigate whether GnRH1, a key reproductive hormone, causally affects ischemic heart disease, finding a positive association.