Longitudinally persistent cerebrospinal fluid B-cells resist treatment in multiple sclerosis
A. L. Greenfield, R. Dandekar, A. Ramesh, E. L. Eggers, H. Wu, S. Laurent, W. Harkin, N. S. Pierson, M. S. Weber, R. G. Henry, A. Bischof, B. A. C. Cree, S. L. Hauser, M. R. Wilson, H.- C. von Büdingen
This study identifies persistent B-cell clones in the cerebrospinal fluid of MS patients despite treatment, suggesting therapy-resistant immune mechanisms in the central nervous system.
bioRxiv · Dec 9, 2018Immunology