Author

A. Brewer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Weinberg· 1 shared B. E. Pflug· 1 shared G. P. Sapkota· 1 shared G. Sathe· 1 shared J. Muller-Greven· 1 shared J. Penfield· 1 shared L. Zhang· 1 shared M. Buck· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

A. Weinberg

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2 papers

Recent·Most cited

Mapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA

A. Brewer, G. Sathe, B. E. Pflug, T. Macartney, G. P. Sapkota

The paper identifies 2,204 potential PPP2CA substrates using proteolysis-targeting chimeras and phospho-proteomic analysis, revealing novel substrates and a pSP/pTP motif preference.

bioRxiv · Sep 19, 2023Cell Biology

Molecular dynamics simulations and functional studies reveal that hBD-2 binds SARS-CoV-2 spike RBD and blocks viral entry into ACE2 expressing cells

L. Zhang, S. K. Ghosh, S. C. Basavarajappa, J. Muller-Greven, J. Penfield, A. Brewer, P. Ramakrishnan, M. Buck, A. Weinberg

The paper shows hBD-2 binds SARS-CoV-2 spike RBD and blocks viral entry into ACE2-expressing cells, with a KD of ~300 nM and IC50 of 2.4 μM.

bioRxiv · Jan 7, 2021 · PreprintBiochemistry