L. Zhang

Marker-specific pixel attribution for single-cell protein quantification with PixAQ

PixAQ improves single-cell protein quantification in imaging mass cytometry by assigning pixel signals to specific markers using spatial and intensity models.

Rice stripe virus utilizes a Laodelphax striatellus salivary carbonic anhydrase to facilitate plant infection by direct molecular interaction

This study identifies a tripartite interaction between rice stripe virus, insect salivary carbonic anhydrase, and a plant protein that facilitates virus infection by enhancing callose degradation.

A fungal pathogen manipulates phytocytokine signaling for plant infection

This study identifies a fungal effector that suppresses plant immunity by enhancing phytocytokine signaling, facilitating pathogen infection.

Proximity labeling reveals dynamic changes in the SQSTM1 protein network

The paper uses proximity labeling to study the dynamic SQSTM1 protein network and shows that aggregated tau alters its interactions with stress-associated proteins.

Dehydrozaluzanin C- derivative protects septic mice by alleviating over-activated inflammatory response and promoting the phagocytosis of macrophages

DHZD reduces inflammation and enhances macrophage phagocytosis in septic mice, showing potential as an HDT agent for bacterial infections.

Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast

The paper humanizes yeast U1 snRNP components to study 5 ss recognition, finding that U1C ZnF substitution causes splicing defects and mitochondrial dysfunction.

SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids

This study shows SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids, upregulating interferon signaling linked to cytokine release syndrome.

A New Large-Scale Extracellular Vesicle Production Strategy for Biomedical Drug Development

This paper introduces a novel large-scale EV production strategy with upstream fed-batch suspension cell culture and downstream chromatographic purification for clinical applications.

Mutations in the IgG B cell receptor associated with class-switched B cell lymphomas

This study identifies mutations in the IgG heavy chain in follicular lymphoma and EZB DLBCL that enhance BCR signalling and oncogenicity by disrupting the IgG intracellular tail.

Adaptive Functions of Structural Variants in Human Brain Development

This study identifies human-specific structural variants in rhesus macaques, showing their impact on human brain development through gene expression changes.

Altruistic feeding and cell-cell signaling during bacterial differentiation actively enhance phenotypic heterogeneity

This study shows that bacterial differentiation through altruistic feeding and cell-cell signaling increases phenotypic heterogeneity, enhancing population resilience to environmental changes.

Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival

Aeromonas hydrophila CobQ is a new type of NAD+- and Zn2+-independent protein lysine deacetylase

This paper identifies AhCobQ as a novel NAD+- and Zn2+-independent lysine deacetylase in Aeromonas hydrophila with unique domain and substrate specificity.

The Genomes of Nematode-Trapping Fungi Provide Insights into the Origin and Diversification of Fungal Carnivorism

This study compares the genomes of nematode-trapping fungi and non-NTF to identify genomic changes linked to carnivorism and adaptation to post-Permian-Triassic extinction environments.

A candidate reference method for the quantification of α-synuclein in cerebrospinal fluid using an SI traceable primary calibrator and multiple reaction monitoring

This paper develops a reference method for quantifying α-synuclein in CSF using SI-traceable calibration and MRM, showing linearity across three orders of magnitude.

ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer

This study identifies ADRA2A as a gene that promotes the classical/progenitor subtype and reduces aggressiveness in pancreatic cancer by altering transcriptome and metabolome profiles.

Cas1 mediates the interference stage in a phage-encoded CRISPR-Cas system

This study identifies Cas1 as mediating the interference stage in a phage-encoded CRISPR-Cas system, revealing its role in connecting Cas2/3 to the DNA-bound Cascade complex.

A 10-valent composite mRNA vaccine against both influenza and COVID-19

This paper introduces FLUCOV-10, a 10-valent mRNA vaccine targeting influenza and SARS-CoV-2, showing robust immune responses and complete protection in mice against multiple strains.

Single-cell multiomics reveals a gene regulatory circuit promoting leukemia cell differentiation

This study uses single-cell multiomics to identify a gene regulatory circuit involving SPI1 and CEBPE that promotes differentiation in APL leukemia cells under ATRA treatment.

Genome-Wide Association Study Reveals Influence of Cell-specific Gene Networks on Soybean Root System Architecture

The paper uses a new root phenotyping system to conduct a GWAS on soybean root system architecture, identifying SNPs and gene networks associated with specific root traits.

Armored Bicistronic CAR T Cells with Dominant-negative TGF-β Receptor II to Overcome Resistance in Glioblastoma.

This paper develops a tri-modular CAR T cell construct with a dominant-negative TGF-β receptor II to overcome GBM resistance by enhancing T cell function and efficacy in a preclinical model.

Design and optimization of novel succinate dehydrogenase inhibitors against agricultural fungi based on Transformer model

This study uses a Transformer model to design novel succinate dehydrogenase inhibitors against agricultural fungi, resulting in potent antifungal compounds through virtual screening and optimization.

The Co-Evolution of Jawed Vertebrates and Interferon Regulatory Factor 5 Generates Unique Inflammation and Innate Immunity

This study identifies IRF5 and IRF6 in cartilaginous fish and shows their evolutionary conservation and functional relevance in innate immunity across jawed vertebrates.

Surface-modified measles vaccines encoding oligomeric, fusion-stabilized SARS-CoV-2 spike glycoproteins bypass measles seropositivity, boosting neutralizing antibody responses to omicron and historical variants.

This study develops a measles-based vaccine encoding SARS-CoV-2 spike glycoproteins that enhances neutralizing antibody responses against both omicron and historical variants.

Proteolytic Cleavage of the ENaC gamma Subunit: Impact Upon Na+ and K+ Handling

This study investigates the impact of proteolytic cleavage of the ENaC gamma subunit on Na+ and K+ handling in mice, finding that cleavage is not essential for channel activity in vivo.

The Primate-Specific Presence of Interferon Regulatory Factor-5 Pseudogene 1

This study identifies IRF5P1, a primate-specific pseudogene that may regulate IRF5 expression through antisense RNA interactions, suggesting a role in primate evolution and immune function.

Systematic Analysis of Immune Changes after B-cell Depletion in Autoimmune Multiple Sclerosis

This study uses single-cell RNA sequencing to analyze immune changes after B-cell depletion in MS patients, revealing cell type-specific effects on macrophages, monocytes, and T cells.

Genomic insights into photosymbiotic evolution in Tridacna squamosa

This study presents the first complete genome of Tridacna squamosa and integrates multi-omics data to uncover molecular mechanisms underlying photosymbiosis with dinoflagellates.

HCCDB v2.0: Decompose the Expression Variations by Single-cell RNA-seq and Spatial Transcriptomics in HCC

HCCDB v2.0 integrates bulk, single-cell, and spatial transcriptomic data from HCC samples to enhance meta-analysis and provide new metrics for gene expression patterns.

Mesenchymal stem cell-derived extracellular vesicles attenuate symptoms in dextran sodium sulfate-induced ulcerative colitis mouse model

This study shows that mesenchymal stem cell-derived extracellular vesicles reduce symptoms in a dextran sulfate sodium-induced ulcerative colitis mouse model by repairing colon mucosa and reducing macrophage infiltration.