Molecular dynamics simulations and functional studies reveal that hBD-2 binds SARS-CoV-2 spike RBD and blocks viral entry into ACE2 expressing cells
L. Zhang, S. K. Ghosh, S. C. Basavarajappa, J. Muller-Greven, J. Penfield, A. Brewer, P. Ramakrishnan, M. Buck, A. Weinberg
The paper shows hBD-2 binds SARS-CoV-2 spike RBD and blocks viral entry into ACE2-expressing cells, with a KD of ~300 nM and IC50 of 2.4 μM.
bioRxiv · Jan 7, 2021 · PreprintBiochemistry