Small molecule inhibitors of G9a reactivate the maternal PWS genes in Prader-Willi-Syndrome patient derived neural stem cells and differentiated neurons
H. Wu, C. Ng, V. Villegas, S. Chamberlain, A. Cacace, O. Wallace
This study shows that G9a inhibitors reactivate maternal PWS genes in patient-derived neural cells and induce downstream PWS-related genes without altering DNA methylation at the PWS-IC.
bioRxiv · May 17, 2019 · PreprintCell Biology