C. Ng

Epigenetic control of multiple genes with a single lentiviral vector encoding transcriptional repressors fused to compact zinc finger arrays

This paper develops a lentiviral system to simultaneously repress multiple genes using zinc finger repressors, showing efficient and long-term gene silencing without DNA editing.

Transcriptional signatures associated with waterlogging stress responses and aerenchyma formation in barley root tissue

This study identifies transcriptional signatures and candidate genes associated with waterlogging stress responses and aerenchyma formation in barley roots.

In vivo selection in non-human primates identifies superior AAV capsids for on-target CSF delivery to spinal cord

The paper identifies superior AAV capsids for targeted spinal cord gene therapy in non-human primates through in vivo selection and evaluates their biodistribution and expression.

Niche-specific macrophage loss promotes skin capillary aging

This study shows that loss of capillary-associated macrophages with age impairs vascular repair and perfusion, revealing limitations in macrophage homeostatic renewal in skin capillaries.

Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14

This study shows TRB proteins recruit JMJ14 to demethylate H3K4me3 and coordinate with PRC2 to repress target genes.

Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegans

This study identifies lipid droplets as a proteostatic mediator in C. elegans that reduces protein ubiquitination, facilitates autophagy, and extends lifespan.

Niche-selective inhibition of pathogenic Th17 cells by targeting metabolic redundancy

This study shows that targeting Gpi1 selectively inhibits pathogenic Th17 cells in autoimmune diseases while sparing homeostatic Th17 cells.

Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes

This study identifies redundant cytokine signals, particularly IL-6, IL-21, and IL-23, that drive Th17 cell differentiation in mesenteric lymph nodes induced by segmented filamentous bacteria.

Small molecule inhibitors of G9a reactivate the maternal PWS genes in Prader-Willi-Syndrome patient derived neural stem cells and differentiated neurons

This study shows that G9a inhibitors reactivate maternal PWS genes in patient-derived neural cells and induce downstream PWS-related genes without altering DNA methylation at the PWS-IC.