Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in Idiopathic Pulmonary Fibrosis
E. Marchal-Duval, M. Homps-Legrand, A. Froidure, M. Jaillet, M. Ghanem, L. Deneuville, A. Justet, A. Maurac, A. Vadel, E. Fortas, A. Cazes, A. Joannes, L. Giersch, H. Mal, P. Mordant, , A. A. Mailleux
This study identifies PRRX1 as a key mesenchymal transcription factor driving lung fibrogenesis in IPF and shows its inhibition reduces fibrotic remodeling.
bioRxiv · Jan 15, 2021Cell Biology