Cell BiologybioRxiv
Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in Idiopathic Pulmonary Fibrosis
E. Marchal-Duval, M. Homps-Legrand, A. Froidure…·A. A. Mailleux
This study identifies PRRX1 as a key mesenchymal transcription factor driving lung fibrogenesis in IPF and shows its inhibition reduces fibrotic remodeling.
DOI 10.7554/elife.79840