Author

A. Chadda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

B. Nguyen· 2 shared T. M. Lohman· 2 shared A. G. Kozlov· 1 shared A. Ruiz Manzano· 1 shared D. Jensen· 1 shared E. A. Galburt· 1 shared E. Galburt· 1 shared E. J. Tomko· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 20 mutual co-author links

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2 shared papersBiophysics

B. Nguyen

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Mycobacterium tuberculosis Ku stimulates multi-round DNA unwinding by UvrD1 monomers

A. Chadda, A. G. Kozlov, B. Nguyen, T. M. Lohman, E. Galburt

This study shows that Mtb Ku stimulates UvrD1 monomers to unwind DNA in multiple rounds, revealing a mechanism for DNA repair activation in mycobacteria.

bioRxiv · Sep 29, 2023 · PreprintBiophysics

Mycobacterium tuberculosis DNA-repair helicase UvrD1 is activated by redox-dependent dimerization via a conserved 2B domain cysteine.

A. Chadda, D. Jensen, E. J. Tomko, A. Ruiz Manzano, B. Nguyen, T. M. Lohman, E. A. Galburt

This study shows that Mtb UvrD1 dimerizes under oxidative conditions, enhancing its DNA unwinding activity through a conserved cysteine in the 2B domain.

bioRxiv · Oct 26, 2021 · PreprintBiochemistry