Author

E. J. Tomko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

E. A. Galburt· 3 shared D. Jensen· 2 shared A. Chadda· 1 shared A. R. Manzano· 1 shared A. Ruiz Manzano· 1 shared A. S. Holehouse· 1 shared A. Soranno· 1 shared B. Nguyen· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBiochemistry

E. A. Galburt

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

High-throughput, fluorescent-aptamer-based measurements of steady-state transcription rates for Mycobacterium tuberculosis RNA polymerase

D. Jensen, A. R. Manzano, E. J. Tomko, M. Rector, M. T. Record, E. A. Galburt

This paper introduces a fluorescent-aptamer-based method to measure steady-state transcription rates of Mycobacterium tuberculosis RNA polymerase with high throughput and precision.

bioRxiv · Mar 13, 2023 · PreprintBiochemistry

Mycobacterium tuberculosis DNA-repair helicase UvrD1 is activated by redox-dependent dimerization via a conserved 2B domain cysteine.

A. Chadda, D. Jensen, E. J. Tomko, A. Ruiz Manzano, B. Nguyen, T. M. Lohman, E. A. Galburt

This study shows that Mtb UvrD1 dimerizes under oxidative conditions, enhancing its DNA unwinding activity through a conserved cysteine in the 2B domain.

bioRxiv · Oct 26, 2021 · PreprintBiochemistry

The role of XPB/Ssl2 double-stranded DNA translocase processivity in transcription start-site scanning.

E. J. Tomko, O. Luyties, J. K. Rimel, C.-L. Tsai, J. O. Fuss, J. Fishburn, S. Hahn, S. E. Tsutakawa, D. J. Taatjes, E. A. Galburt

This study compares the dsDNA translocase activity of holo- and core-TFIIH complexes in yeast and humans, finding that human core-TFIIH lacks processive translocation, unlike yeast core-TFIIH which also lacks it but has reduced ATPase activity.

Journal of Molecular Biology · Jul 1, 2021Peer-reviewedBiochemistry

Shelterin components modulate nucleic acids condensation and phase separation in the context of telomeric DNA

A. Soranno, J. J. Incicco, P. De Bona, E. J. Tomko, E. Galburt, A. S. Holehouse, R. Galletto

The paper shows TRF2 drives single telomere condensation and multi-telomere phase separation, with hRap1 modulating these processes.

bioRxiv · Apr 30, 2021Biophysics