Author

A. Chadwick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Alfirevic· 1 shared A. L. Ball· 1 shared Bettina WilmiD· 1 shared C. E. Jolly· 1 shared C. Trott· 1 shared J. Bennett· 1 shared J. Lyon· 1 shared P. A. Murray· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 16 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Alfirevic

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2 papers

Recent·Most cited

Analysis of haemolysis-based injury in immortalised proximal tubule epithelial cells is impaired by haemoglobin interference with bioluminescence assays.

C. Trott, J. Bennett, P. A. Murray, A. Chadwick, S. J. McWilliam, Bettina Wilm

This study shows that haemoglobin from haemolysed plasma interferes with bioluminescence assays in ciPTECs, but does not severely injure the cells.

bioRxiv · Nov 9, 2026 · PreprintPhysiology

The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury: a translational in vitro study

A. L. Ball, C. E. Jolly, J. Lyon, A. Alfirevic, A. Chadwick

This study generates HepG2 transmitochondrial cybrids with mtDNA haplogroups H and J to assess their susceptibility to mitochondrial toxicants, finding haplogroup J shows greater sensitivity to certain drugs.

eLife · Jun 6, 2023Peer-reviewedPharmacology & Toxicology