J. Bennett

Brain Charts for the Rhesus Macaque Lifespan

This study creates normative brain growth charts for rhesus macaques across their lifespan using MRI data, revealing developmental milestones and cross-species comparisons with humans.

Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation

The paper identifies a splicing mechanism in AML independent of mutations, showing it drives poor prognosis and can be targeted with PRMT5 inhibition.

Pervasive relaxed selection in termite genomes

This study compares termite and cockroach genomes to find relaxed selection in termites, linked to reduced population size and caste-related adaptations.

Delivery of loaded MR1 Monomer Results in Efficient Ligand Exchange to Host MR1 and Subsequent MR1T cell activation

The paper demonstrates that delivering MR1 monomers loaded with 5-OP-RU enables ligand exchange to host MR1, leading to MR1T cell activation.

T Cell Predominant Response to AAV-Spike Protects hACE2 Mice from SARS-CoV-2 Pneumonia

This study shows that AAV6 and AAV9 vaccines induce cellular immunity protecting mice from SARS-CoV-2 pneumonia without relying on neutralizing antibodies.

Phase Resolution of Heterozygous Sites in Diploid Genomes is Important to Phylogenomic Analysis under the Multispecies Coalescent Model

This study evaluates the impact of phase resolution strategies on phylogenomic analyses under the multispecies coalescent model, finding that random phasing leads to biased parameter estimates.

Integer linear programming outperforms simulated annealing for solving conservation planning problems

This study compares Simulated Annealing and Integer Linear Programming for conservation planning, finding ILP produces cheaper and faster solutions with additional practical benefits.

Structural insights into interaction mechanisms of alternative piperazine-urea YEATS domain binders in MLLT1

The paper characterizes piperazine-urea derivatives as acetyl/acyl-lysine mimetics for MLLT1 and reveals distinct interaction mechanisms through crystal structures.

Development of a Confinable Gene-Drive System in the Human Disease Vector, Aedes aegypti.

This paper develops CRISPR-based split-gene drives in Aedes aegypti with high cleavage and transmission rates, demonstrating their potential for safe and reversible population control.

Prioritize diversity or declining species? Trade-offs and synergies in spatial planning for the conservation of migratory birds in the face of land cover change

The paper evaluates trade-offs between conserving migratory bird diversity and decline hotspots, showing differing spatial priorities under various land cover change scenarios.

Global distribution of earthworm diversity

The paper predicts global patterns of earthworm diversity, abundance, and biomass using a dataset from 7000 sites, finding climate drives these patterns but with differences from aboveground taxa.

Optimizing the conservation of migratory species over their full annual cycle

This study evaluates land prioritization strategies for conserving migratory birds by comparing annual vs. weekly optimization and inclusion of human-dominated lands.

Rapid covalent-probe discovery by electrophile fragment screening

This study develops a method for discovering covalent probes using electrophile fragment screening and identifies selective inhibitors for OTUB2 and NUDT7.