Profiling Active Enzymes for Polysorbate Degradation in Biotherapeutics by Activity-Based Protein Profiling
X. Li, D. Chandra, S. Letarte, G. Adam, J. Welch, R.-S. Yang, S. Bodea, A. Dow, A. Chi, C. Strulson, D. Richardson
This study uses activity-based protein profiling to identify active enzymes causing polysorbate degradation in biotherapeutic production, finding more enzymes than traditional proteomics methods.
bioRxiv · Oct 7, 2020Bioengineering