The SARS-CoV-2 spike protein binds and modulates estrogen receptors
O. Solis, A. R. Beccari, D. Iaconis, C. Talarico, C. A. Ruiz-Bedoya, J. C. Nwachukwu, A. Cimini, V. Castelli, R. Bertini, M. Montopoli, V. Cocetta, S. Borocci, I. G. Prandi, K. Flavahan, M. Bahr, , M. Michaelides
This study identifies a novel interaction between SARS-CoV-2 spike protein and estrogen receptor alpha, showing its role in modulating ER activity and ACE2 expression in infected cells and tissues.
bioRxiv · May 21, 2022Immunology