Author

M. Michaelides

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 1 Assay:organoid / primary culture· 1 Assay:proteomics· 1

Frequent Co-Authors

A. R. Beccari· 2 shared C. Talarico· 2 shared D. Iaconis· 2 shared M. Allegretti· 2 shared R. Bertini· 2 shared A. Cimini· 1 shared A. D. Axtman· 1 shared A. Kalitzeos· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCell Biology

A. R. Beccari

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Relevance of the viral Spike protein/cellular Estrogen Receptor-α interaction for endothelial-based coagulopathy induced by SARS-CoV-2

S. S. Barbieri, F. Cattani, L. Sandrini, M. M. Grillo, C. Talarico, D. Iaconis, L. Lione, E. Salvatori, P. Amadio, G. Garoffolo, M. Maffei, F. Galli, A. R. Beccari, E. Marra, M. Zoppi, , M. Pesce

This study investigates how the SARS-CoV-2 Spike protein interacts with the estrogen receptor-α to enhance pro-coagulant activity in endothelial cells, leading to thrombosis risk.

bioRxiv · Oct 4, 2022 · PreprintCell Biology

The SARS-CoV-2 spike protein binds and modulates estrogen receptors

O. Solis, A. R. Beccari, D. Iaconis, C. Talarico, C. A. Ruiz-Bedoya, J. C. Nwachukwu, A. Cimini, V. Castelli, R. Bertini, M. Montopoli, V. Cocetta, S. Borocci, I. G. Prandi, K. Flavahan, M. Bahr, , M. Michaelides

This study identifies a novel interaction between SARS-CoV-2 spike protein and estrogen receptor alpha, showing its role in modulating ER activity and ACE2 expression in infected cells and tissues.

bioRxiv · May 21, 2022Immunology

Translational readthrough as a potential therapeutic for AIPL1-associated Leber Congenital Amaurosis in a patient-derived iPSC-retinal organoid model

A. Leung, A. Sacristan-Reviriego, P. Perdigao, H. Sai, M. Georgiou, A. Kalitzeos, A.-J. F. Carr, P. J. Coffey, M. Michaelides, J. Bainbridge, M. E. Cheetham, J. van der Spuy

This study uses patient-derived iPSC-retinal organoids to investigate translational readthrough as a therapy for LCA4 caused by AIPL1 mutations.

bioRxiv · Dec 17, 2021 · PreprintCell Biology

The Kinase Chemogenomic Set (KCGS): An open science resource for kinase vulnerability identification

C. I. Wells, H. Al-Ali, D. M. Andrews, C. R. M. Asquith, A. D. Axtman, M. Chung, I. Dikic, D. Ebner, J. Elkins, P. Ettmayer, C. Fischer, M. Frederiksen, N. S. Gray, S. B. Hatch, S. Knapp, , D. H. Drewry

The paper introduces the Kinase Chemogenomic Set (KCGS), a curated collection of 187 selective kinase inhibitors covering 215 human kinases, for use in cell-based screens.

bioRxiv · Dec 22, 2019Cell Biology