Inhibition of HDAC7 reprograms the histone H3.3 landscape to induce heterochromatin spreading and DNA replication defects in cancer cells.
O. Hassan, M. Pizzagalli, O. Leary, J. P. Zepecki, A. Corseri, L. J. Wu, S. Sasipalli, D. Lee, L. Hayward, L. Tran, E. Fajardo, A. Fiser, D. Karambizi, N. Tapinos
This study shows that inhibiting HDAC7 alters H3.3 deposition and chromatin structure, leading to DNA replication defects and increased sensitivity to DNA damage in cancer cells.
bioRxiv · Mar 12, 2024Cancer Biology