L. Tran

Aggressive KRAS mutations direct TGF-β response towards partial EMT in patient-derived colorectal cancer tumoroids

This study investigates how TGF-β affects colorectal cancer tumoroids, finding that aggressive KRAS mutations lead to partial EMT and increased invasiveness.

Impaired Suppression of Plasma Lipid Extraction and its Partitioning Away from Muscle by Insulin in Humans with Obesity

This study examines how insulin affects lipid extraction from plasma in lean and obese individuals, finding impaired lipid partitioning away from muscle in obese insulin-resistant humans.

KRas, in addition to Tp53 is a driver for early carcinogenesis and a molecular target in a mouse model of invasive gastro-esophageal adenocarcinoma

This study identifies KRAS mutation as a driver of invasive gastro-esophageal adenocarcinoma in a mouse model, showing its synergistic role with Tp53 or Rb1 loss and potential as a therapeutic target.

Higher prevalence of sacbrood virus in highbush blueberry pollination units

The study investigates pathogen prevalence in honey bees during highbush blueberry pollination, finding higher sacbrood virus levels in bees near blueberry fields post-pollination.

Inhibition of HDAC7 reprograms the histone H3.3 landscape to induce heterochromatin spreading and DNA replication defects in cancer cells.

This study shows that inhibiting HDAC7 alters H3.3 deposition and chromatin structure, leading to DNA replication defects and increased sensitivity to DNA damage in cancer cells.

De novo design of diverse small molecule binders and sensors using Shape Complementary Pseudocycles

The paper designs nanomolar binders for diverse small molecules using a pseudocycle-based shape complementarity method, enabling direct conversion into sensing systems.

Radial glia promote microglial development through integrin aVb8 -TGFb1 signaling

This study shows radial glia use integrin aVb8-TGFb1 signaling to promote microglial development, with disruptions causing dysmature microglia and neuromotor symptoms.

An in vitro experimental pipeline to characterize the binding specificity of SARS-CoV-2 neutralizing antibodies

This paper characterizes the binding specificity and epitope of a broadly neutralizing anti-SARS-CoV-2 Spike RBD antibody using mAb-resistant virions and cryo-EM structural analysis.

Autotrophic adaptive laboratory evolution of the acetogen Clostridium autoethanogenum delivers the gas-fermenting strain LAbrini with superior growth, products, and robustness

This study evolves C. autoethanogenum through adaptive laboratory evolution to create a strain with faster growth, better product profile, and improved robustness in continuous cultures.

Evolution of ipsilateral breast cancer decoded by proteogenomics

This study uses proteogenomics to analyze primary breast cancers and their ipsilateral recurrences, identifying molecular changes linked to recurrence and genomic instability.

Modular automated microfluidic cell culture platform reduces glycolytic stress in cerebral cortex organoids

The paper develops an automated microfluidic platform for cerebral cortex organoids that reduces glycolytic and endoplasmic reticulum stress compared to conventional cultures.

Mimicking tumor cell heterogeneity of colorectal cancer in a patient-derived organoid-fibroblast model

This paper develops a colorectal cancer organoid model incorporating patient-derived fibroblasts, showing enhanced cellular heterogeneity and morphology compared to mono-cultures.

Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction

The paper identifies mutation-specific pathophysiological mechanisms in SATB1 variants causing distinct neurodevelopmental disorders.

Resolving the spatial and cellular architecture of lung adenocarcinoma by multi-region single-cell sequencing

This study uses multi-region single-cell sequencing to map the spatial and cellular architecture of early-stage lung adenocarcinoma, revealing geospatial lineage evolution and potential therapeutic targets.

The McdAB system positions α-carboxysomes in proteobacteria

The paper shows that the McdAB system positions α-carboxysomes in proteobacteria, distinct from its role in cyanobacteria, and suggests horizontal transfer of the system from proteobacteria to cyanobacteria.

Estimating invasion dynamics with geopolitical-unit level records: performance and similarity of common methods using both simulated data and a real case

This paper evaluates eight methods for estimating invasion dynamics using geopolitical-unit data, finds CEB and regression methods perform best, and shows boundary displacement methods are most accurate for spread rates and dynamics.

TRIM21 and PHLDA3 Negatively Regulate the Cross-Talk between the PI3K/AKT Pathway and PPP Metabolism

This study shows TRIM21 and PHLDA3 regulate cross-talk between PI3K/AKT signaling and PPP metabolism, with implications for cancer therapy.

CpG-creating Mutations are Costly in Many Human Viruses

The paper examines the cost of CpG-creating mutations in various human viruses using existing genomic data and finds they are generally costly.