Author

A. Fiser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

N. Tapinos· 4 shared D. Karambizi· 3 shared C. Guetta-Terrier· 2 shared E. Fajardo· 2 shared J. E. Fajardo· 2 shared J. P. Zepecki· 2 shared J.-S. Chen· 2 shared S. A. Toms· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersCancer Biology

N. Tapinos

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Inhibition of HDAC7 reprograms the histone H3.3 landscape to induce heterochromatin spreading and DNA replication defects in cancer cells.

O. Hassan, M. Pizzagalli, O. Leary, J. P. Zepecki, A. Corseri, L. J. Wu, S. Sasipalli, D. Lee, L. Hayward, L. Tran, E. Fajardo, A. Fiser, D. Karambizi, N. Tapinos

This study shows that inhibiting HDAC7 alters H3.3 deposition and chromatin structure, leading to DNA replication defects and increased sensitivity to DNA damage in cancer cells.

bioRxiv · Mar 12, 2024Cancer Biology

Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA charge mimicry to enhance chaperone efficiency

B. M. Lorton, C. Warren, H. Ilyas, P. Nandigrami, S. Hegde, S. Cahill, S. M. Lehman, J. Shabanowitz, D. Hunt, A. Fiser, D. Cowburn, D. Shechter

The paper shows that glutamylation of acidic IDRs in Npm2 and Nap1 enhances their DNA mimicry function, improving histone chaperone efficiency in nucleosome assembly.

bioRxiv · Sep 18, 2023Biochemistry

Engineering GliaTrap: a biodegradable non-swelling hydrogel with tuned release of CXCL12 to attract migrating glioblastoma cells

Y. Suita, S. Miriyala, D. Merih-Toruner, W. Yue, L. Xie, B. Akobundu, N. Perch, A. Fiser, E. Fajardo, J. Shen, N. Tapinos

GliaTrap is a biodegradable non-swelling hydrogel with tuned release of a chemoattractant to attract invading glioma cells and serve as delivery platform for local therapeutics.

bioRxiv · Apr 12, 2023 · PreprintCancer Biology

Chi3l1 is a modulator of glioma stem cell states and a therapeutic vulnerability for glioblastoma

C. Guetta-Terrier, D. Karambizi, B. Akosman, J.-S. Chen, S. Kamle, J. E. Fajardo, A. Fiser, R. Singh, S. A. Toms, C. G. Lee, J. A. Elias, N. Tapinos

This study shows Chi3l1 modulates glioma stem cell states by altering transcription factor activity and cell state transitions, and demonstrates anti-Chi3l1 antibody treatment inhibits glioblastoma growth.

bioRxiv · Oct 1, 2021 · PreprintCancer Biology

miRNA-mediated loss of m6A increases nascent translation in glioblastoma

J. P. Zepecki, D. Karambizi, J. E. Fajardo, K. M. Snyder, C. Guetta-Terrier, O. Y. Tang, J.-S. Chen, A. Sarkar, A. Fiser, S. A. Toms, N. Tapinos

The paper shows that miRNA-mediated loss of m6A increases nascent translation in glioblastoma stem cells during differentiation.

bioRxiv · Aug 28, 2020Cancer Biology