Endogenous retroviruses drive KRAB zinc-finger family protein expression for tumor suppression
J. Ito, I. Kimura, A. Soper, A. Coudray, Y. Koyanagi, H. Nakaoka, I. Inoue, P. Turelli, D. Trono, K. Sato
The paper shows HERV activation in tumors upregulates KZFPs, which suppress cancer progression by downregulating cell cycle and adhesion genes, improving disease outcomes.
bioRxiv · Feb 2, 2020Cancer Biology