Author

D. Grun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

D. Trono· 3 shared E. Planet· 2 shared J. Duc· 2 shared J. Pontis· 2 shared A. Aharonov· 1 shared A. Auger· 1 shared A. Coudray· 1 shared A. Harari· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersEvolutionary Biology

D. Trono

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Targeting PD-L1 in solid cancer with myeloid cells expressing a CAR-like immune receptor

K. M. Chen, D. Grun, B. Gautier, S. Venkatesha, M. Maddox, A.-H. Zhang, P. Andersen

This study demonstrates that engineered myeloid cells expressing a PD-1-based CAR-like receptor can recognize and attack PD-L1+ solid tumors, enhancing phagocytosis and slowing tumor growth in vivo.

bioRxiv · Jan 29, 2024 · PreprintImmunology

Primate-specific cis- and trans-regulators shape transcriptional networks during human development

J. Pontis, D. Trono, C. Pulver, E. Planet, D. Grun, S. Offner, J. Duc, A. Manfrin, M. P. Lutolf

The paper identifies primate-specific transposable elements and their regulatory factors that influence transcriptional networks during human development.

bioRxiv · Aug 18, 2021 · PreprintEvolutionary Biology

Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons

D. Trono, P. Turelli, C. Playfoot, D. Grun, C. Raclot, J. Pontis, A. Coudray, C. Thorball, J. Duc, E. V. Pankevich, B. Deplancke, V. Busskamp

The paper identifies primate-specific KZFPs that repress retrotransposons in human neurons, influencing differentiation and preventing neurotoxic responses.

bioRxiv · Nov 29, 2019Evolutionary Biology

Integrated Proteogenomic Deep Sequencing and Analytics Accurately Identify Non-Canonical Peptides in Tumor Immunopeptidomes

C. Chong, M. Muller, H. Pak, D. Harnett, F. Huber, D. Grun, M. Leleu, A. Auger, M. Arnaud, B. J. Stevenson, J. Michaux, I. Bilic, A. Hirsekorn, L. Calviello, L. Simo-Riudalbas, , M. Bassani-Sternberg

The paper develops an MS-based proteogenomic approach to identify non-canonical HLA peptides in tumors, finding hundreds of shared and tumor-specific peptides, including an immunogenic one from ABCB5.

bioRxiv · Sep 6, 2019Cancer Biology

A metabolic switch from OXPHOS to glycolysis is essential for cardiomyocyte proliferation in the regenerating heart

H. Honkoop, D. de Bakker, A. Aharonov, F. Kruse, A. Shakked, P. Nguyen, C. de Heus, L. Garric, M. Muraro, A. Shoffner, F. Tessadori, J. Peterson, W. Noort, G. Posthuma, D. Grun, , J. Bakkers

This study identifies a metabolic switch from OXPHOS to glycolysis in regenerating zebrafish hearts, showing it is essential for cardiomyocyte proliferation and heart regeneration.

bioRxiv · Dec 18, 2018Cell Biology