Author

I. Kimura

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 14 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 14 Research Focus:host-pathogen & immune response· 14 Organism:human· 13 Assay:proteomics· 4 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2 Organism:virus· 2

Frequent Co-Authors

K. Sato· 12 shared The Genotype to Phenotype Japan (G2P-Japan) Consortium· 12 shared J. Ito· 10 shared K. Uriu· 9 shared Y. Kosugi· 9 shared D. Yamasoba· 8 shared A. Saito· 7 shared T. Ikeda· 7 shared

Activity by Year

2018-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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12 shared papersMicrobiology

K. Sato

Mutual co-authors in cluster

Author profile →

15 papers

Recent·Most cited

Determination of the factors responsible for host tropism of SARS-CoV-2-related bat coronaviruses

S. Fujita, Y. Kosugi, I. Kimura, K. Tokunaga, The Genotype to Phenotype Japan (G2P-Japan) Consortium, J. Ito, K. Sato

The paper identifies specific residues in the spike protein and ACE2 receptor that determine the host tropism of two SARS-CoV-2-related bat coronaviruses.

bioRxiv · Apr 13, 2023 · PreprintMicrobiology

Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5

T. Tamura, D. Yamasoba, Y. Oda, J. Ito, T. Kamasaki, N. Nao, R. Hashimoto, Y. Fujioka, R. Suzuki, L. Wang, H. Ito, I. Kimura, I. Yokota, M. Kishimoto, M. Tsuda, , T. Fukuhara

This study compares the pathogenicity of SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.5, finding BA.5 is more fusogenic and induces stronger inflammation than earlier variants.

bioRxiv · Aug 5, 2022Microbiology

Virological characteristics of the SARS-CoV-2 Omicron BA.2.75

A. Saito, T. Tamura, J. Zahradnik, S. Deguchi, K. Tabata, I. Kimura, J. Ito, H. Nasser, M. Toyoda, K. Nagata, K. Uriu, Y. Kosugi, S. Fujita, D. Yamasoba, M. Shofa, , Kei Sato

This study investigates the virological characteristics of SARS-CoV-2 Omicron BA.2.75, finding it has higher transmissibility and pathogenicity compared to BA.2 and BA.5, but similar sensitivity to antiviral drugs.

bioRxiv · Jul 14, 2022Microbiology

Virological characteristics of the novel SARS-CoV-2 Omicron variants including BA.2.12.1, BA.4 and BA.5

I. Kimura, D. Yamasoba, T. Tamura, N. Nao, Y. Oda, S. Mitoma, J. Ito, H. Nasser, J. Zahradnik, K. Uriu, S. Fujita, Y. Kosugi, L. Wang, M. Tsuda, M. Kishimoto, , K. Sato

This study analyzes the virological characteristics of SARS-CoV-2 Omicron variants BA.2.12.1, BA.4, and BA.5, finding they have higher reproduction numbers, reduced neutralization by prior immunity, increased replication in lung cells, and greater pathogenicity in hamsters compared to BA.2.

bioRxiv · May 26, 2022Microbiology

Sensitivity of novel SARS-CoV-2 Omicron subvariants, BA.2.11, BA.2.12.1, BA.4 and BA.5 to therapeutic monoclonal antibodies

D. Yamasoba, Y. Kosugi, I. Kimura, S. Fujita, K. Uriu, J. Ito, K. Sato, The Genotype to Phenotype Japan (G2P-Japan) Consortium

This study evaluates the sensitivity of new Omicron subvariants to eight therapeutic monoclonal antibodies, finding increased resistance in BA.4/5 to cilgavimab compared to BA.2.

bioRxiv · May 3, 2022Microbiology

SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant

I. Kimura, D. Yamasoba, H. Nasser, J. Zahradnik, Y. Kosugi, J. Wu, K. Nagata, K. Uriu, Y. L. Tanaka, J. Ito, R. Shimizu, T. S. Tan, E. P. Butlertanaka, H. Asakura, K. Sadamasu, , K. Sato

This study identifies the S375F mutation in the Omicron spike protein as responsible for its reduced cleavage efficiency, fusogenicity, and rapid spread.

bioRxiv · Apr 3, 2022Microbiology

Virological characteristics of SARS-CoV-2 BA.2 variant

D. Yamasoba, I. Kimura, H. Nasser, Y. Morioka, N. Nao, J. Ito, K. Uriu, M. Tsuda, J. Zahradnik, K. Shirakawa, R. Suzuki, M. Kishimoto, Y. Kosugi, K. Kobiyama, T. Hara, , Sawa

This study compares the virological characteristics of SARS-CoV-2 BA.2 and BA.1 variants, finding BA.2 has higher transmissibility, different antigenicity, greater replicative capacity, and higher pathogenicity in hamsters.

bioRxiv · Feb 14, 2022Microbiology

SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion

B. Meng, I. Ferreira, A. Abdullahi, N. Goonawardane, A. Saito, I. Kimura, D. Yamasoba, S. A. Kemp, G. Papa, S. Fatihi, S. Rathore, P. Perera Gerba, T. Ikeda, M. Toyoda, T. S. Tan, , S. Zepeda

This study investigates the immune escape, infectivity, and cell-cell fusion properties of SARS-CoV-2 Omicron BA.1 compared to Delta, showing higher ACE2 affinity and antibody evasion but similar antiviral drug efficacy.

bioRxiv · Dec 17, 2021Microbiology

Ineffective neutralization of the SARS-CoV-2 Mu variant by convalescent and vaccine sera

K. Uriu, I. Kimura, K. Shirakawa, A. Takaori-Kondo, T.-a. Nakada, A. Kaneda, The Genotype to Phenotype Japan (G2P-Japan) Consortium, S. Nakagawa, K. Sato

This study shows that Mu variant is highly resistant to neutralization by convalescent and vaccine sera compared to other variants.

bioRxiv · Sep 6, 2021Microbiology

SARS-CoV-2 Lambda variant exhibits higher infectivity and immune resistance

I. Kimura, Y. Kosugi, J. Wu, D. Yamasoba, E. P. Butlertanaka, Y. L. Tanaka, Y. Liu, K. Shirakawa, Y. Kazuma, R. Nomura, Y. Horisawa, K. Tokunaga, A. Takaori-Kondo, H. Arase, The Genotype to Phenotype Japan (G2P-Japan) Consortium, , K. Sato

The paper investigates the SARS-CoV-2 Lambda variant, finding it more infectious due to specific mutations and better immune evasion, contributing to its spread in South America.

bioRxiv · Jul 28, 2021Microbiology

SARS-CoV-2 spike P681R mutation, a hallmark of the Delta variant, enhances viral fusogenicity and pathogenicity

A. Saito, T. Irie, R. Suzuki, T. Maemura, H. Nasser, K. Uriu, Y. Kosugi, K. Shirakawa, K. Sadamasu, I. Kimura, J. Ito, J. Wu, K. Iwatsuki-Horimoto, M. Ito, S. Yamayoshi, , K. Sato

This study shows the P681R mutation in the SARS-CoV-2 spike protein enhances fusogenicity and pathogenicity in the Delta variant compared to the prototypic virus.

bioRxiv · Jun 17, 2021Microbiology

An emerging SARS-CoV-2 mutant evading cellular immunity and increasing viral infectivity

C. Motozono, M. Toyoda, J. Zahradnik, T. Ikeda, A. Saito, T. S. Tan, I. Ngare, H. Nasser, I. Kimura, K. Uriu, Y. Kosugi, S. Torii, A. Yonekawa, N. Shimono, Y. Nagasaki, , K. Sato

This study identifies two SARS-CoV-2 mutations, L452R and Y453F, that evade HLA-restricted cellular immunity and increase viral infectivity.

bioRxiv · Apr 2, 2021Microbiology

SARS-CoV-2 ORF3b is a potent interferon antagonist whose activity is further increased by a naturally occurring elongation variant

Y. Konno, I. Kimura, K. Uriu, M. Fukushi, T. Irie, Y. Koyanagi, S. Nakagawa, K. Sato

This paper shows that SARS-CoV-2 ORF3b is a potent interferon antagonist, with a naturally occurring longer variant enhancing its anti-interferon activity in severe COVID-19 cases.

bioRxiv · May 11, 2020Microbiology

Endogenous retroviruses drive KRAB zinc-finger family protein expression for tumor suppression

J. Ito, I. Kimura, A. Soper, A. Coudray, Y. Koyanagi, H. Nakaoka, I. Inoue, P. Turelli, D. Trono, K. Sato

The paper shows HERV activation in tumors upregulates KZFPs, which suppress cancer progression by downregulating cell cycle and adhesion genes, improving disease outcomes.

bioRxiv · Feb 2, 2020Cancer Biology

Gorilla APOBEC3 restricts SIVcpz and influences lentiviral evolution in great ape cross-species transmissions

Y. Nakano, K. Yamamoto, A. Soper, R. Kumata, H. Aso, N. Misawa, Y. Konno, I. Kimura, S. Nagaoka, G. Juarez-Fernandez, J. Ito, T. Ikeda, Y. Koyanagi, R. S. Harris, K. Sato

This study shows that gorilla APOBEC3G restricts SIVcpz transmission and that a single amino acid change in Vif allows viral evasion, influencing lentiviral evolution in great apes.

bioRxiv · Jul 4, 2018 · PreprintMicrobiology