Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes
S. Preissler, C. Rato, Y. Yan, L. A. Perera, A. Czako, D. Ron
This study shows that calcium depletion affects BiP-substrate interactions by altering ADP affinity, impacting ER proteostasis and UPR activation.
bioRxiv · Nov 3, 2020Biochemistry