D. Ron

A genome wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α

The paper uses a CRISPR/Cas9 screen to identify calreticulin as a repressor of ATF6α signaling in the unfolded protein response.

Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the Integrated Stress Response

The paper identifies a mechanism by which eIF2γ binding to PPP1R15A enhances catalytic efficiency of the holophosphatase that terminates the integrated stress response.

Dynamics of p53 DNA binding sites contributes to functional selectivity of p53-driven gene expression

This study shows that DNA flexibility of p53 response elements influences the timing and efficiency of p53-driven gene expression, affecting cellular responses to stress.

Higher order phosphatase-substrate contacts terminate the Integrated Stress Response

The paper presents a Cryo-EM structure of the PP1c/PPP1R15A/G-actin complex that terminates the Integrated Stress Response by positioning eIF2's phosphoserine-51 at the active site.

Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD

This paper presents crystallographic and solution structures of the FICD-BiP deAMPylation complex, revealing how FICD switches between AMPylation and deAMPylation activities through conformational changes.

Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes

This study shows that calcium depletion affects BiP-substrate interactions by altering ADP affinity, impacting ER proteostasis and UPR activation.

ISRIB blunts the integrated stress response by allosterically antagonising the inhibitory effect of phosphorylated eIF2 on eIF2B

This study shows ISRIB inhibits the integrated stress response by antagonizing eIF2(P)-induced inhibition of eIF2B through allosteric effects.

Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers

This study identifies genes and cargo receptors involved in the ER export of pathogenic α1-antitrypsin polymers using a CRISPR screen.

GDF15 and the beneficial actions of metformin in pre-diabetes

This study shows metformin increases GDF15 levels, which is necessary for its weight loss and insulin-sensitizing effects in both humans and mice.

An oligomeric state-dependent switch in FICD regulates AMPylation and deAMPylation of the chaperone BiP

This paper identifies how FICD switches between AMPylation and deAMPylation of BiP by changing its oligomeric state, regulated by ATP/ADP levels.

Choice of PP1 catalytic subunit affects neither requirement for G-actin nor insensitivity to Sephin1 of PPP1R15A-regulated eIF2αP dephosphorylation

The paper shows that the choice of PP1 catalytic subunit does not affect the requirement for G-actin or sensitivity to Sephin1 in PPP1R15A-regulated eIF2αP dephosphorylation.

TriPer, an optical probe tuned to the endoplasmic reticulum, tracks H2O2 consumption by glutathione

The paper develops TriPer, an optical probe that detects H2O2 in the ER, revealing glutathione's role in H2O2 turnover during protein folding.