Y. Yan

A distant TANGO1 family member promotes vitellogenin export from the ER in C. elegans

This study identifies TNGL-1 as a C. elegans TANGO1 family member that facilitates vitellogenin export from the ER by engaging cargo via a luminal domain.

Genomic evolution reshapes cell type diversification in the amniote brain

The paper creates a single-cell atlas of amniote brains to study cell type diversification and identifies species-specific gene expression patterns and novel cell subtypes.

Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in Glioblastoma

This study uses single-cell transcriptomics to analyze GBM tumor microenvironment, identifying immunosuppressive macrophage subtypes and exhausted NK cells, suggesting therapeutic targets.

Ferroptosis mediates the progression of hyperuricemic nephropathy by activating RAGE signaling

This study shows ferroptosis contributes to hyperuricemic nephropathy by activating RAGE signaling, and inhibiting ferroptosis improves renal injury and fibrosis in a mouse model.

Snorkel-tag Based Affinity Chromatography for Recombinant Extracellular Vesicle Purification

This paper introduces a Snorkel-tag system for affinity purification of extracellular vesicles using CD81 fused with tags and transmembrane domains, enabling non-destructive isolation and future applications in tracing and analyzing EVs.

African Swine Fever Virus Protein B263R Inhibits Autophagy by Promoting Proteasomal Degradation of Beclin1

This study identifies B263R as an ASFV protein that inhibits autophagy by promoting proteasomal degradation of Beclin1, highlighting its role in viral replication and potential therapeutic targets.

Unravelling biomolecular and community grammars of RNA granules via machine learning

This study uses machine learning to identify RNA granule proteins in the human proteome, revealing key physicochemical features and protein interaction networks.

Mesenchymal stem cell-derived extracellular vesicles attenuate symptoms in dextran sodium sulfate-induced ulcerative colitis mouse model

This study shows that mesenchymal stem cell-derived extracellular vesicles reduce symptoms in a dextran sulfate sodium-induced ulcerative colitis mouse model by repairing colon mucosa and reducing macrophage infiltration.

3D Bioprinting of Human Neural Tissues with Functional Connectivity

This study develops a 3D bioprinting platform to create human neural tissues with functional connectivity, showing differentiation into neurons and astrocytes and forming functional circuits.

Therapeutic targeting of KRAS mutation-driven tumorigenesis by extracellular vesicles loaded with small interfering RNA

This study demonstrates that extracellular vesicles loaded with KRAS-targeting siRNA can inhibit tumor growth in mouse models, both intratumorally and intravenously.

Integrated Hfq-interacting RNAome and transcriptomic analysis reveals complex regulatory networks of nitrogen fixation in root-associated Pseudomonas stutzeri A1501

This study identifies Hfq-binding RNAs in Pseudomonas stutzeri A1501 using eCLIP-seq, revealing new regulatory targets involved in nitrogen fixation and other metabolic processes.

Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the Integrated Stress Response

The paper identifies a mechanism by which eIF2γ binding to PPP1R15A enhances catalytic efficiency of the holophosphatase that terminates the integrated stress response.

Combined Partial-Nitrification and Phosphorus Removal with the co-existence of Nitrite-resistant phosphorous accumulating organisms (PAOs) and nitrifiers in the treatment of high-strength manure digestate

This study demonstrates the coexistence of nitrite-resistant PAOs and nitrifiers in a reactor treating manure digestate, achieving efficient nitrogen and phosphorus removal through optimized aeration schemes.

Nitrite deteriorates bioreactor performance by reducing growth of Ca. Brocadia sapporoensis instead of inhibiting the anammox activity

This study shows that nitrite reduces the growth of Ca. Brocadia sapporoensis in anammox systems, leading to performance collapse, rather than directly inhibiting anammox activity.

Buffering effects of nonspecifically DNA-bound RNA polymerases in bacteria

This study shows nonspecifically DNA-bound RNA polymerases in bacteria buffer free RNAP concentration, reducing crosstalk between rRNA and mRNA transcription, and are evolutionarily advantageous.

Resident memory T cell development is associated with AP-1 transcription factor upregulation across anatomical niches.

This study identifies AP-1 transcription factors as key regulators of TRM development across tissues using scRNA-seq and ATAC-seq, revealing a novel mechanism for TRM reactivation.

Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma

This study shows that KRAS inhibition in lung adenocarcinoma leads to an AT1-like cell state that drives resistance, and targeting these cells improves treatment response.

ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer

This study identifies ONECUT2 as a master transcription factor that drives resistance in prostate cancer through multiple mechanisms, including activation of neuroendocrine and adenocarcinoma variants, and shows that its inhibition can suppress treatment-resistant lineage plasticity.

Adaptive immunity: from CRISPR to CRIHSP?

The paper identifies CRIHSP structures in human adaptive immunity genes, showing their association with genomic instability and recombination.

Pseudorabies virus causes splenic injury via inducing the oxidative stress and apoptpsos related factors in mice

This study shows PRV infection increases oxidative stress and apoptosis in mouse spleen, with elevated ROS and MDA levels and reduced antioxidant enzymes.

Habitat loss weakens the positive relationship between grassland plant richness and above-ground biomass

This study examines how habitat loss and fragmentation affect plant richness, above-ground biomass, and their relationship in grassland communities using structural equation modeling.

Distinct Microstructural Heterogeneities Underpin Specific Micromechanical Properties in Human ACL Femoral and Tibial Entheses

This study identifies distinct microstructural and biomolecular features in ACL femoral and tibial entheses that contribute to their specific mechanical properties.

Artemisitene protected against murine schistosomiasis japonica through anti-parasite activity and immune regulation

This paper shows artemisitene reduces Schistosoma japonicum infection and liver damage in mice by killing parasites and modulating immune responses.

Eyes on nature: Embedded vision cameras for multidisciplinary biodiversity monitoring

The paper introduces a portable, low-power embedded vision camera system for biodiversity monitoring, demonstrating its application across multiple ecological disciplines with classification accuracies between 55% and 96%.

Interchromosomal Colocalization with Parental Genes Is Linked to the Function and Evolution of Mammalian Retrocopies

This study shows that retrocopies and their parental genes colocalize in 3D genome organization, leading to increased transcription, translation, and evolutionary conservation.

Unravelling Biosynthesis and Biodegradation Potentials of Microbial Dark Matters in Hypersaline Lakes

This study identifies novel biosynthesis and biodegradation potentials in microbial dark matter from hypersaline lakes, expanding genetic resources for biotechnology.

Targeted Protein O-GlcNAcylation Using Bifunctional Small Molecules

This paper develops OGTACs, bifunctional small molecules that enable protein-specific O-GlcNAcylation in cells, with applications for studying and targeting this modification in disease.

Cryo-EM structures of Kv1.2 potassium channels, conducting and non-conducting

The paper presents cryo-EM structures of Kv1.2 potassium channels in different states, revealing new insights into selectivity filter stability and toxin block mechanisms.

Prokaryotic Gabija complex senses and executes nucleotide depletion and DNA cleavage for antiviral defense

The paper identifies the Gabija complex's mechanism of sensing nucleotide depletion and executing DNA cleavage for antiviral defense, showing its unique synergy between GajA and GajB.

Revisiting the role of Acinetobacter sp. in EBPR systems

The paper investigates the role of Acinetobacter in EBPR systems using 16S sequencing and SCRS-FISH, finding Acinetobacter dominance and its contribution to phosphorus removal under specific operational conditions.