CXCR4 and MIF are required for neutrophil extracellular trap release triggered by Plasmodium-infected erythrocytes
D. S. A. Rodrigues, E. B. Prestes, L. d. S. Silva, A. A. S. Pinheiro, J. M. C. Ribeiro, A. Dicko, P. E. Duffy, M. Fried, I. M. B. Francischetti, E. M. Saraiva, H. A. Paula-Neto, M. T. Bozza
The paper shows that Plasmodium-infected erythrocytes release MIF, which triggers CXCR4-dependent NET formation by neutrophils, contributing to parasite control in malaria.
bioRxiv · Nov 22, 2019Immunology