Regulation of inflammation and protection against invasive pneumococcal infection by the long pentraxin PTX3
R. Porte, R. Silva-Gomes, C. Theroude, R. Parente, F. Asgari, M. Sironi, F. Pasqualini, S. Valentino, R. Asselta, C. Recordati, A. Doni, A. Inforzato, C. Rodriguez-Gallego, I. Obando, E. Colino, , A. Mantovani
This study investigates the role of PTX3 in regulating inflammation and resistance to invasive pneumococcal infection in mice and humans, finding that PTX3 deficiency increases susceptibility and enhances neutrophil inflammation.
bioRxiv · Apr 14, 2022Immunology