Author

A. E. Lindsay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:human· 1

Frequent Co-Authors

A. A. Carr· 1 shared A. J. Bernoff· 1 shared A. M. Santos· 1 shared A. Navarro Hernandez· 1 shared A. Ponjavic· 1 shared A. Tilevik· 1 shared B. C. Lagerholm· 1 shared C. Macleod· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperImmunology

A. A. Carr

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2 papers

Recent·Most cited

Short time diffusive fluxes over membrane receptors yields the direction of a signaling source

A. J. Bernoff, A. Navarro Hernandez, A. E. Lindsay

The paper develops a method to determine the direction of a signaling source by analyzing early diffusive flux arrivals to membrane receptors, showing that directional information is encoded in early arrivals.

bioRxiv · Mar 30, 2023 · PreprintBiophysics

A cell-topography based mechanism for ligand discrimination by the T-cell receptor

R. A. Fernandes, K. A. Ganzinger, J. Tzou, P. Jonsson, S. F. Lee, M. Palayret, A. M. Santos, A. A. Carr, A. Ponjavic, V. T. Chang, C. Macleod, B. C. Lagerholm, A. E. Lindsay, O. Dushek, A. Tilevik, , D. Klenerman

This paper develops a model showing T-cell receptors discriminate ligands based on dwell-time in phosphatase-depleted contacts constrained by cell topography, predicting signaling potency without multi-step proof-reading.

Proceedings of the National Academy of Sciences · Jun 20, 2019Peer-reviewedImmunology