Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1
A. Ehlen, C. Martin, S. Miron, M. Julien, F. X. Theillet, V. Ropars, G. Sessa, R. Beaurepere, V. Boucherit, P. Duchambon, A. El Marjou, S. Zinn Justin, A. Carreira
This study shows that BRCA2 phosphorylation by PLK1 is essential for proper chromosome alignment during mitosis, distinct from its DNA repair role, and its disruption leads to aneuploidy.
bioRxiv · Oct 26, 2019Cell Biology