Author

S. Miron

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Assay:DNA methylation· 1 Assay:protein structure· 1

Frequent Co-Authors

S. ZINN-JUSTIN· 4 shared R. Ghouil· 3 shared A. Carreira· 2 shared A. N. Zelensky· 2 shared D. Ristic· 2 shared M. Julien· 2 shared P. Legrand· 2 shared R. Kanaar· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersCell Biology

S. ZINN-JUSTIN

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Author profile →

5 papers

Recent·Most cited

KIF2C-induced nuclear condensation concentrates PLK1 and phosphorylated BRCA2 at the kinetochore microtubules in mitosis

A. Skobelkina, M. Julien, S. Jeannin, S. Miron, T. Egger, R. Chaaban, G. Bouvignies, R. Ghouil, C. Friel, D. BUSSO, F.-X. Theillet, R. Le Bars, A. Carreira, A. Constantinou, J. Basbous, S. ZINN-JUSTIN

The paper shows KIF2C forms condensates during mitosis that concentrate PLK1 and phosphorylated BRCA2 at kinetochore microtubules, enhancing their kinase activity and attachment stability.

bioRxiv · Apr 13, 2024Cell Biology

DMC1 and RAD51 bind FxxA and FxPP motifs of BRCA2 via two separate interfaces

S. Miron, P. Legrand, S. E. van Rossum-Fikkert, D. Ristic, A. Badar, R. Kanaar, S. Zinn-Justin, A. N. Zelensky

This paper explains how BRCA2's FxxA and FxPP motifs bind to DMC1 and RAD51 via distinct interfaces, stabilizing recombinase filaments and explaining functional differences between these proteins.

bioRxiv · Oct 5, 2023Biochemistry

BRCA2-HSF2BP Oligomeric Ring Disassembly by BRME1 Promotes Homologous Recombination

R. Ghouil, S. Miron, K. Sato, D. Ristic, S. E. van Rossum-Fikkert, P. Legrand, M. Ouldali, J.-M. Winter, V. Ropars, G. David, A.-A. Arteni, C. Wyman, P. Knipscheer, R. Kanaar, A. N. Zelensky, S. Zinn-Justin

The paper shows that BRME1 disrupts the HSF2BP-BRCA2 ring complex, preventing BRCA2 degradation and promoting homologous recombination in meiosis.

bioRxiv · Apr 27, 2023Biochemistry

Polθ is phosphorylated by Polo-like kinase 1 (PLK1) to enable repair of DNA double strand breaks in mitosis

C. Gelot, M. T. Kovacs, S. Miron, E. Mylne, R. Ghouil, T. Popova, F. Dingli, D. Loew, J. Guirouilh-Barbat, E. Del Nery, S. Zinn-Justin, R. Ceccaldi

This study identifies Polθ as a key factor in repairing DNA double strand breaks during mitosis, showing that its phosphorylation by PLK1 enables this process and maintains genome integrity.

bioRxiv · Mar 17, 2023Cell Biology

Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1

A. Ehlen, C. Martin, S. Miron, M. Julien, F. X. Theillet, V. Ropars, G. Sessa, R. Beaurepere, V. Boucherit, P. Duchambon, A. El Marjou, S. Zinn Justin, A. Carreira

This study shows that BRCA2 phosphorylation by PLK1 is essential for proper chromosome alignment during mitosis, distinct from its DNA repair role, and its disruption leads to aneuploidy.

bioRxiv · Oct 26, 2019Cell Biology