C. Martin

A 20-year time-series of a freshwater lake reveals seasonal dynamics and environmental drivers of viral diversity, ecology, and evolution

The paper analyzes a 20-year viral time-series in a freshwater lake to uncover seasonal dynamics, environmental drivers, and evolutionary patterns of viral diversity and ecology.

SAR324 and related lineages are associated with the evolutionary history and origins of dsr-mediated sulfur oxidation

This study investigates the evolutionary history of sulfur oxidation by analyzing SAR324 and related bacterial phyla, finding that they are linked to the origins of the reverse dsr pathway.

Multiple performance peaks for scale-biting in an adaptive radiation of pupfishes

The paper analyzes feeding kinematics in pupfishes to identify performance peaks associated with adaptation to a novel trophic niche, using deep learning for automated motion tracking.

In vitro phenotypic susceptibility of HIV-1 non-group M to CCR5 inhibitor (Maraviroc): TROPI-CO study

This study evaluates the phenotypic susceptibility of HIV-1 non-group M strains to Maraviroc, showing variability linked to tropism and highlighting the need for additional parameters beyond IC50 values.

Life in a Central European warm-temperate to subtropical open forest: paleoecology of the rhinocerotids from Ulm-Westtangente (Aquitanian, early Miocene, Germany)

This study analyzes the paleoecology of two rhinocerotid species from the early Miocene using multi-proxy data, revealing differences in diet and habitat preferences while confirming warm-temperate to subtropical climate conditions.

Spatial and temporal control of lysis by the lambda holin

The paper investigates the molecular basis of polar lysis in phage λ using time lapse fluorescence microscopy, finding that the holin forms two-dimensional rafts at cell poles before lysis.

The impact of chemical pollution across major life transitions: a meta-analysis on oxidative stress in amphibians

This study meta-analyzes the impact of chemical pollution on oxidative stress in amphibians across life stages, finding divergent antioxidant responses and oxidative damage post-metamorphosis.

Metabolic influence of core ciliates within the rumen microbiome

The paper investigates the metabolic roles of core ciliates in the rumen microbiome, finding that they contribute significantly to volatile fatty acid production and hydrogen metabolism, particularly in high methane-emitting animals.

Dual role of striatal astrocytes in behavioral flexibility and metabolism in the context of obesity

This study shows that striatal astrocytes regulate behavioral flexibility and metabolism in obesity through chemogenetic manipulation in mice.

Identification of small molecule antivirals against HTLV-1 by targeting the hDLG1-Tax-1 protein-protein interaction

The paper identifies a small molecule that inhibits the Tax-1-hDLG1 interaction, reducing HTLV-1 cell-to-cell transmission in a T-cell model.

Comparative proximity biotinylation implicates RAB18 in sterol mobilization and biosynthesis

This study uses proximity biotinylation to identify RAB18 interactors, revealing its role in sterol mobilization and biosynthesis, with implications for Warburg Micro syndrome.

Tumor Niche Network-Defined Subtypes Predict Immunotherapy Response of Esophageal Squamous Cell Cancer

This study defines ESCC subtypes based on tumor microenvironment transcriptional networks and predicts immunotherapy response using single-cell transcriptomics.

Nanobody CDR3 mimetics enhance SOS1-catalyzed nucleotide exchange on RAS

This study shows that CDR3 mimetics can enhance SOS1-catalyzed nucleotide exchange on RAS, demonstrating functional modulation of protein-protein interactions through structural mimicry of a nanobody.

Dually biofortified cisgenic tomatoes with increased flavonoids and branched-chain amino acids content

This paper describes the development of cisgenic tomatoes enriched in flavonoids and branched-chain amino acids (BCAAs) through genetic engineering, showing significant increases in both metabolites and potential health benefits.

Key Genetic Determinants Driving Esophageal Squamous Cell Carcinoma Initiation and Immune Evasion

This study identifies key genetic drivers of ESCC initiation and immune evasion using CRISPR/Cas9 in murine organoids and human scRNA-seq data.

The genomes of medicinal skullcaps reveal the polyphyletic origins of clerodane diterpene biosynthesis in the family Lamiaceae.

This study reveals polyphyletic origins of clerodane diterpene biosynthesis in Lamiaceae by analyzing genomes and metabolic pathways of three species.

GIP receptor reduces osteoclast activity and improves osteoblast survival by activating multiple signaling pathways

This study shows GIP reduces osteoclast activity and improves osteoblast survival through multiple signaling pathways, suggesting GIPR agonism could treat osteoporosis.

Butyrate differentiates permissiveness to Clostridioides difficile infection and influences growth of diverse C. difficile isolates

This study shows butyrate reduces C. difficile fitness in mice and humans, and inhibits growth of diverse C. difficile isolates, suggesting dietary interventions could help prevent CDI.

Hypothalamic astrocyte control systemic glucose metabolism and energy balance via regulation of extra-synaptic glutamate signaling

This study shows that hypothalamic astrocytes regulate systemic glucose metabolism and energy balance through extra-synaptic glutamate signaling, offering new targets for obesity treatment.

CaMK1D signaling in AgRP neurons promotes ghrelin-mediated food intake

This paper identifies CaMK1D as a key mediator of ghrelin-induced food intake in AgRP neurons, showing its role in promoting orexigenic neuropeptide expression and obesity resistance.

Trophic specialization on unique resources in one of the most celebrated examples of sympatric speciation, Barombi Mbo crater lake cichlids

The paper quantitatively analyzes dietary niche partitioning in Barombi Mbo cichlids, finding little trophic niche partitioning but evidence of dietary specialization on rare resources.

Femtosecond laser microdissection isolating regenerating C. elegans neurons for single cell RNA sequencing

This study introduces femtosecond laser microdissection (fs-LM) to isolate regenerating C. elegans neurons for single-cell RNA sequencing, revealing gene modules linked to axon regrowth rates.

Nonadaptive radiation of the gut microbiome in an adaptive radiation of Cyprinodon pupfishes with minor shifts for scale-eating

The paper compares gut microbiota of specialized and generalist Cyprinodon pupfishes, finding minor adaptive shifts in scale-eaters but overall phylogenetic conservation, suggesting nonadaptive microbiome divergence.

Direct differentiation of Dental Pulp Pluripotent-like Stem Cells differentiation into Hepatocyte-like Cells

This study demonstrates the differentiation of dental pulp pluripotent-like stem cells into functional hepatocyte-like cells using a serum-free protocol.

Neuraminidase inhibitors rewire neutrophil function in vivo in murine sepsis and ex vivo in COVID-19

This paper shows neuraminidase inhibitors reduce neutrophil overactivation in sepsis and COVID-19 by inhibiting sialic acid release and ROS production.

Rapid Evolution of Plastic-degrading Enzymes Prevalent in the Global Ocean

The paper identifies oceanic PETase variants in marine metagenomes, showing their prevalence and potential role in plastic degradation.

Natural killer activation for bladder cancer elimination can be achieved in vitro by heat-killed BCG

The paper shows that heat-killed BCG substrains activate NK cells to eliminate bladder cancer cells in vitro, with Tice, Connaught, and Moreau strains being most effective.

A new perspective on the evolution of the interaction between the Vg/VGLL1-3 proteins and the TEAD transcription factors

The paper investigates the structural and functional evolution of Vg/VGLL1-3 proteins' interaction with TEAD transcription factors, revealing an additional {Omega}-loop in some variants.

Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1

This study shows that BRCA2 phosphorylation by PLK1 is essential for proper chromosome alignment during mitosis, distinct from its DNA repair role, and its disruption leads to aneuploidy.

Ecological divergence in sympatry causes gene misregulation in hybrids

The paper investigates gene misregulation in hybrids of sympatric pupfish species and finds that divergent ecological selection leads to hybrid gene misregulation, potentially acting as a reproductive barrier.