Sapropterin Treatment Prevents Congenital Heart Defects Induced by Pregestational Diabetes in Mice
A. Engineer, T. Saiyin, X. Lu, A. S. Kucey, B. L. Urquhart, T. A. Drysdale, K. Norozi, Q. Feng
This study shows sapropterin reduces congenital heart defects in mouse offspring of diabetic mothers by improving eNOS coupling and cell proliferation.
bioRxiv · Jul 23, 2018Pharmacology & Toxicology