Q. Feng

Channel width modulates the permeability of DNA origami based nuclear pore mimics

The paper investigates how varying the width of DNA origami-based nuclear pore mimics affects permeability, showing that narrower pores restrict viral capsid passage while wider pores allow it with NTR assistance.

NK Cell Exhaustion in Wilson's Disease Revealed by Single-cell RNA Sequencing Predicts the Prognosis of Cholecystitis

This study uses single-cell RNA sequencing to show NK cell exhaustion in Wilson's disease is linked to worse cholecystitis outcomes.

P66 is a bacterial mimic of CD47 that binds the anti-phagocytic receptor SIRPα and facilitates macrophage evasion by Borrelia burgdorferi

This study identifies P66, a bacterial protein mimicking CD47, which binds SIRPα to evade macrophage phagocytosis, and shows its role in Lyme Disease pathogenesis.

Effect of Electroacupuncture Pretreatment on Cognitive Impairment and Mitophagy in Aging Model Rats and its mechanism

This study investigates how electroacupuncture pretreatment affects cognitive impairment and mitophagy in aging rats, finding it improves cognitive function by enhancing mitophagy and mitochondrial function.

Large-scale multi-omics analyses identified root-microbiome associations underlying plant nitrogen nutrition

The paper identifies root-microbiome associations affecting plant nitrogen nutrition through multi-omics analyses of 1,341 rapeseed samples.

Rationally designed multimeric nanovaccines using icosahedral DNA origami for molecularly controlled display of SARS-CoV-2 receptor binding domain

This study designs multimeric nanovaccines using icosahedral DNA origami to display SARS-CoV-2 RBD, showing enhanced B cell activation and immune responses in mice.

SMB controls decompartmentalization in Arabidopsis root cap cells to execute programmed cell death

The paper identifies SMB-controlled decompartmentalization events and ion fluxes in Arabidopsis root cap cells that execute programmed cell death.

Simulations suggest robust microtubule attachment of kinesin and dynein in antagonistic pairs

The paper uses simulations to study kinesin and dynein motor dynamics in bidirectional transport, finding that matched stall forces and independent detachment rates best replicate experimental velocity distributions.

Kinesin-1, -2 and -3 motors use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport

The paper investigates how kinesin-1, -2, and -3 motors compete with dynein during bidirectional transport and finds that all three families can withstand hindering loads through distinct kinetic strategies.

Biochemical characterization of a Mycobacterium tuberculosis prolyl dipeptidyl peptidase that displays a remarkable thermostability

This study characterizes a Mycobacterium tuberculosis dipeptidyl peptidase with high thermal stability and shows its potential role in immune modulation.

Regulation of protein translation by TRIM21

This study identifies TRIM21 as a regulator of PKR-mediated protein translation by modulating PP1 ubiquitination and eIF2 dephosphorylation, revealing its role in antiviral defense and potential therapeutic applications.

The infiltration pattern of microenvironmental cells and different immune escape mechanisms in colorectal cancer

The paper identifies three TME cell subtypes in colorectal cancer and their associated immune escape mechanisms using transcriptomic data from public datasets.

Autophagy promotes programmed cell death and corpse clearance in specific cell types of the Arabidopsis root cap

Novel Association of Lyme Disease, Age, and Atopic Dermatitis

This study identifies a novel association between Lyme disease, age, and atopic dermatitis using both murine models and human epidemiological data.

Genome context influences evolutionary flexibility of nearly identical type III effectors in two phytopathogenic Pseudomonads

The paper investigates how genome context influences the evolutionary flexibility of nearly identical type III effectors in two phytopathogenic Pseudomonads through ICE elements.

Mitochondria transplantation between living cells

This study develops a method to transplant mitochondria between living cells and shows donor mtDNA replication in recipient cells without selection pressure.

OsMADS58 stabilizes gene regulatory circuits during rice stamen development

This study identifies OsMADS58's role in stabilizing gene regulatory circuits during rice stamen development using CRISPR knockout and transcriptomic analysis.

Lactate Increases Stemness of CD8+ T Cells to Augment Anti-Tumor Immunity

This study shows lactate enhances CD8+ T cell stemness and improves anti-tumor immunity by increasing Tcf7 expression through histone acetylation.

Single-shot rAAV5-based Vaccine Provides Long-term Protective Immunity against SARS-CoV-2 and Its Variants

This study develops a single-dose rAAV5-based vaccine that provides long-term immunity against SARS-CoV-2 and its variants with high neutralizing antibody titers and safety.

Quantitative Phosphoproteomic Analyses Identify STK11IP as a Lysosome-Specific Substrate of mTORC1 that Regulates Lysosomal Acidification

This study identifies STK11IP as a lysosome-specific mTORC1 substrate that regulates lysosomal acidification and autophagy, with implications for therapeutic targeting of autophagy-related diseases.

The SARS-CoV-2 host cell membrane fusion protein TMPRSS2 is a tumor suppressor and its downregulation correlates with increased antitumor immunity and immunotherapy response in lung adenocarcinoma

This study shows TMPRSS2 is a tumor suppressor in lung adenocarcinoma, with its downregulation linked to enhanced antitumor immunity and better response to immunotherapy.

In vivo co-registered hybrid-contrast imaging by successive photoacoustic tomography and magnetic resonance imaging

This paper presents a hardware-software solution for co-registering photoacoustic tomography and MRI images in vivo, demonstrating hybrid-contrast imaging of tumor microenvironments.

A scalable method for identifying recombinants from unaligned sequences

This paper introduces a scalable method to identify recombinant sequences from unaligned data, demonstrating its effectiveness on malaria parasite var genes.

The mechanism of motor inhibition by microtubule-associated proteins

This study investigates how microtubule-associated proteins (MAPs) regulate motor protein interactions, finding that MAPs inhibit motors without blocking their binding sites and that motors must interact with MAPs to move on MAP-coated microtubules.

Genome diversity and quorum sensing variations in laboratory strains of Pseudomonas aeruginosa PAO1

This study examines genetic and phenotypic variations in Pseudomonas aeruginosa PAO1 sublines due to microevolution, showing how mutations in lasR and mexT affect quorum sensing and virulence.

Dynactin p150 promotes processive motility of DDB complexes by minimizing diffusional behavior of dynein

The paper uses iSCAT microscopy to analyze dynein-dynactin-BicD2 motility, finding that p150 reduces diffusive behavior and enhances processive movement.

Single cell RNA sequencing reveals cellular diversity of trisomy 21 retina

This study uses single-cell RNA sequencing to analyze the cellular diversity and molecular markers in the retina of a trisomy 21 fetus, revealing communication networks and novel markers.

Integration of gut microbiome, host biomarkers, and urine metabolome data reveals networks of interactions associated with distinct clinical phenotypes

Sapropterin Treatment Prevents Congenital Heart Defects Induced by Pregestational Diabetes in Mice

This study shows sapropterin reduces congenital heart defects in mouse offspring of diabetic mothers by improving eNOS coupling and cell proliferation.

Isolation and Purification of Active Antimicrobial Peptides from Hermetia illucens L., and Its Effects on CNE2 Cells

The paper isolates and purifies an antimicrobial peptide HI-3 from Hermetia illucens larvae and shows it inhibits CNE2 cell proliferation and induces apoptosis without affecting normal cells.