Deficient uracil base excision repair leads to persistent dUMP in HIV proviruses during infection of monocytes and macrophages
M. Meshesha, A. Esadze, J. Cui, N. Churgulia, S. K. Sahu, J. T. Stivers
This study shows that monocytes lack functional uracil base excision repair, leading to persistent dUMP in HIV proviruses, while macrophages have limited hUNG2 activity, affecting viral infectivity and diversification.
PLOS ONE · Jul 14, 2020Peer-reviewedMicrobiology