J. Cui

Phase transition of WTAP regulates m6A modification of interferon-stimulated genes

The paper shows WTAP undergoes phase transition during IFN-β stimulation to regulate m6A modification of ISG mRNAs and control their expression.

The fully activated open state of KCNQ1 controls the cardiac 'fight-or-flight' response

This paper identifies the fully activated open state of KCNQ1 as critical for β-adrenergic stimulation of IKs channels, showing that modulators enhancing this state can restore function in LQT1 mutants.

A Near Infrared Fluorescent Nanosensor for Spatial and Dynamic Measurements of Auxin, Indole-3-Acetic Acid, in Planta

This paper introduces a near infrared fluorescent nanosensor for spatial and dynamic measurement of IAA in planta, showing species independence and functionality in plant cells.

Intestinal microbiome dysbiosis increases Mycobacteria pulmonary colonization in mice by regulating the Nos2-associated pathways

This study shows gut microbiome dysbiosis in mice increases Mycobacterium tuberculosis lung colonization by altering Nos2 pathways via the gut-lung axis.

VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent tumorigenesis by engaging p300

This study identifies VGLL2 and TEAD1 fusion proteins as YAP/TAZ-independent drivers of tumorigenesis by recruiting p300 for epigenetic regulation.

Octopus "Hypnosis": Inducing Tonic Immobility for Studying Local Sensorimotor Responses and Arm-Sucker Coordination

The paper introduces a modified tonic immobility method for octopuses to study local sensorimotor responses and arm-sucker coordination without full anesthesia.

The gut microbiota is essential for Trichinella spiralis-evoked suppression of colitis

This study shows that Trichinella spiralis infection protects against colitis in mice by altering the gut microbiota, increasing SCFA-producing bacteria, and enhancing goblet cell differentiation and IL-10 levels.

Targeting GFPT2 to reinvigorate immunotherapy in EGFR-mutated NSCLC

This study identifies GFPT2 as a metabolic checkpoint in EGFR-mutated NSCLC that promotes immune evasion, and shows that targeting GFPT2 enhances PD-1 blockade therapy.

CDC5L surveils cellular stress responses and stress granule formation through transcriptional repression

This study identifies CDC5L as a transcriptional repressor that prevents spontaneous stress granule formation by suppressing PERK-eIF2 signaling.

SARS-CoV-2 spike protein induces the cytokine release syndrome by stimulating T cells to produce more IL-2

This study identifies that SARS-CoV-2 spike protein induces cytokine release syndrome by enhancing T cell production of IL-2, which drives inflammatory cytokine release through TLR4 and NF-κB activation.

The PDIM paradox of Mycobacterium tuberculosis: new solutions to a persistent problem

The paper identifies a metabolic deficiency causing PDIM loss in Mycobacterium tuberculosis and shows how nutrient supplementation can restore PDIM production and virulence.

Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasomeinduced blood coagulation and inflammation

This study shows that inhibiting NINJ1 reduces procoagulant microvesicle release and inflammation during pyroptosis, protecting against blood coagulation and lethality.

Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression

This study shows that inhibiting subchondral osteoclastogenesis maintains hypoxia in subchondral bone, slowing osteoarthritis progression by stabilizing HIF-1 and reducing cartilage degeneration.

Atherosclerosis is a smooth muscle cell-driven tumor-like disease

This study shows atherosclerosis shares tumor-like features with smooth muscle cells, including genomic instability and cancer gene networks, and demonstrates anti-cancer drugs can treat it.

A critical role of VEGFR2 in lymphatic tumor metastasis

This study shows that VEGFR2 in lymphatic endothelial cells promotes tumor metastasis by regulating lymphatic valve formation and tumor-associated lymphangiogenesis.

Arrhythmia-associated Calmodulin Variants Interact with KCNQ1 to Confer Aberrant Membrane Trafficking and Function

This study investigates how arrhythmia-associated calmodulin variants affect KCNQ1 binding, membrane trafficking, and function, revealing variable impacts on cardiac ion channel regulation.

"Tumor Treating Fields" delivered via electromagnetic induction have varied effects across glioma cell lines and electric field amplitudes

This study applies electromagnetic fields to glioma cell lines and finds variable effects on proliferation and gene expression, contradicting previous in vitro findings of consistent anti-proliferative effects.

Retinoic acid signaling modulates smooth muscle cell phenotypic switching in atherosclerosis through epigenetic regulation of gene expression

This study shows that retinoic acid signaling reduces SEM cell formation and atherosclerosis by epigenetically repressing SEM cell marker genes through RAR/EZH2 complex recruitment and histone modification changes.

TRPV1-mediated sonogenetic neuromodulation of motor cortex in freely moving mice

This study demonstrates that TRPV1-mediated sonogenetics can safely modulate motor cortex activity in mice, inducing behavioral changes without significant tissue damage.

Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP

This study shows that replication-competent HIV persists in alveolar macrophages and monocytes despite high dUTP levels and low UNG activity, suggesting dUMP incorporation does not fully block viral replication in vivo.

The senescence regulator S40 family members from Caragana intermedia and Arabidopsis thaliana inhibit leaf senescence via promoting cytokinins synthesis

This study identifies CiS40-11 and its orthologs AtS40-5 and AtS40-6 as regulators of leaf senescence that promote cytokinin synthesis by inhibiting MYB2 expression.

Single-cell RNA-sequencing analysis reveals the molecular mechanism of subchondral bone cell heterogeneity in the development of osteoarthritis

The paper uses single-cell RNA sequencing to identify novel cell subsets in subchondral bone of OA patients and elucidates their roles in disease progression.

An allosteric agonist activates BK channels by perturbing coupling between Ca2+ binding and pore opening

The paper identifies BC5, an allosteric agonist that modulates BK channel activation by disrupting the coupling between Ca2+ binding and pore opening.

A Genome-wide CRISPR Screen Identifies WDFY3 as a Novel Regulator of Macrophage Efferocytosis

This study identifies WDFY3 as a novel regulator of macrophage efferocytosis through a genome-wide CRISPR screen, revealing its role in actin depolymerization and lysosomal acidification.

Parasite defensive limb movements enhance signal attraction in male little torrent frogs: insight into the evolution of multimodal signals

The paper shows that parasite-induced limb movements in male frogs enhance the attractiveness of acoustic signals by incorporating visual elements, influencing female mate choice.

Evolution and Genetic Diversity of the Retroviral Envelope in Anamniotes

This study identifies and classifies 25,498 gamma-type Env-containing ERVs in anamniotes, revealing genetic diversity and evolutionary patterns through phylogenomic analysis.

Principles of sensor-effector organization in six-transmembrane ion channels

The paper uses statistical coupling analysis to study sensor-effector organization in TRP and Kv ion channels, identifying conserved core sectors and family-specific accessory sectors with three localization principles.

Viromes in Marine Ecosystems Reveal Remarkable Invertebrate RNA Virus Diversity

This study identifies 315 new RNA viruses in marine invertebrates, revealing hidden diversity and potential host switching events in ocean viromes.

Adipocyte Tribbles1 Regulates Plasma Adiponectin and Plasma Lipids in Mice

This study shows that adipocyte Trib1 regulates plasma adiponectin, cholesterol, and triglycerides in mice, confirming human genetic associations and revealing a novel mechanism for Trib1's role in lipid metabolism.

Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects

This study identifies C28 as a compound that modulates IKs channel voltage sensor activation, reversing drug-induced APD prolongation without affecting normal APD.