J. T. Stivers

This study shows that guanine-containing ssDNA and RNA induce dimeric or tetrameric SAMHD1, with tetramers being inactive for dNTPase and RNase activity.

This study shows that replication-competent HIV persists in alveolar macrophages and monocytes despite high dUTP levels and low UNG activity, suggesting dUMP incorporation does not fully block viral replication in vivo.

This study shows that phosphorylation of SAMHD1 at Thr592 increases tetramer dynamics and ssDNA binding, leading to rapid inactivation of dNTPase activity at stalled replication forks.

This study shows that monocytes lack functional uracil base excision repair, leading to persistent dUMP in HIV proviruses, while macrophages have limited hUNG2 activity, affecting viral infectivity and diversification.