Porphyromonas gingivalis fuels colorectal cancer through CHI3L1-mediated iNKT cell-driven immune evasion
A. Diaz Basabe, G. Lattanzi, F. Perillo, C. Amoroso, A. Baeri, A. Farini, Y. Torrente, G. Penna, M. Rescigno, M. Ghidini, E. Cassinotti, L. Baldari, L. Boni, M. Vecchi, F. Caprioli, , F. Strati
This study shows Porphyromonas gingivalis promotes colorectal cancer by inducing iNKT cells to express CHI3L1, reducing their cytotoxicity and enabling immune evasion.
bioRxiv · Dec 29, 2023Immunology