This study shows Porphyromonas gingivalis promotes colorectal cancer by inducing iNKT cells to express CHI3L1, reducing their cytotoxicity and enabling immune evasion.

bioRxiv · Dec 29, 2023Immunology

Aging affects reprogramming of murine pulmonary capillary endothelial cells after lung injury

M. Truchi, M. Gautier-Isola, G. Savary, H. Cadis, C. Scribe, A. Baeri, A. Lingampally, V. Magnone, C. Girard-Riboulleau, M.-J. Arguel, C. de Schutter, J. Fassy, N. Boukrout, R. Larrue, N. Martin, , B. Mari

This study compares transcriptomic changes in pulmonary capillary endothelial cells from young and aged mice after lung injury, finding age-related differences in resolution and fibrotic signatures.

bioRxiv · Jul 11, 2023 · PreprintPathology

Blockade of pro-fibrotic response mediated by the miR-143/-145 cluster prevents targeted therapy-induced phenotypic plasticity and resistance in melanoma

S. Diazzi, A. Baeri, J. Fassy, M. Lecacheur, O. Marin-Bejar, C. Girard, L. Lefevre, C. Lacoux, M. Irondelle, C. Mounier, M. Truchi, M. Couralet, A. Carminati, I. Berestjuk, F. Larbret, , S. Tartare-Deckert

This study identifies the miR-143/-145 cluster as a driver of therapy-resistant mesenchymal-like phenotype in melanoma and shows that blocking its pro-fibrotic effects enhances MAPK inhibitor efficacy.

bioRxiv · Jul 2, 2021Cancer Biology

Identification of oncolytic vaccinia restriction factors in canine high-grade mammary tumor cells using single-cell transcriptomics

B. Cambien, K. Lebrigand, A. Baeri, N. Nottet, C. Compin, A. Lamit, O. Ferraris, C. Peyrefitte, V. Magnone, J. Henriques, L.-E. Zaragosi, S. Giorgetti-Peraldi, F. Bost, M. Gautier-Isola, R. Rezzonico, , G. Vassaux

This paper uses single-cell transcriptomics to identify DDIT4 as a resistance factor against oncolytic vaccinia virus in canine TNBC cells.

bioRxiv · May 29, 2020Cancer Biology