M. Vecchi

Hybridization load introduced by Alpine ibex hybrid swarms

The paper estimates hybridization load in Alpine ibex due to hybridization with domestic goats, finding increased loss-of-function mutations in hybrids compared to non-hybrids.

Estrogen-related differences in antitumor immunity and the gut microbiome contribute to sexual dimorphism of colorectal cancer

Porphyromonas gingivalis fuels colorectal cancer through CHI3L1-mediated iNKT cell-driven immune evasion

This study shows Porphyromonas gingivalis promotes colorectal cancer by inducing iNKT cells to express CHI3L1, reducing their cytotoxicity and enabling immune evasion.

miRNome profiling of lung cancer metastases revealed a key role for miRNA-PD-L1 axis in the modulation of chemotherapy response

The paper identifies a miR-455-5p/PD-L1 axis that drives chemotherapy resistance in lung cancer metastases and predicts neoadjuvant chemotherapy response.

Decellularized Normal and Tumor Extracellular Matrix as Scaffold for Cancer Organoid Cultures of Colorectal Peritoneal Metastases

The paper develops 3D organoid cultures using decellularized ECM from colorectal peritoneal metastases to model the metastatic niche and assess chemotherapy response.