Structural basis of substrate transport and drug recognition by the human thiamine transporter SLC19A3
F. Gabriel, L. Spriestersbach, A. Fuhrmann, K. E. J. Jungnickel, S. Mostafavi, E. Pardon, J. Steyaert, C. Loew
This study determines the cryo-EM structures of the human thiamine transporter SLC19A3 in complex with ligands, revealing its transport mechanism and drug interactions.
bioRxiv · Mar 11, 2024 · PreprintBiochemistry