C. Loew

Structural basis of substrate transport and drug recognition by the human thiamine transporter SLC19A3

This study determines the cryo-EM structures of the human thiamine transporter SLC19A3 in complex with ligands, revealing its transport mechanism and drug interactions.

Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition

The paper investigates the substrate recognition mechanism of the bacterial POT DtpB using structural and biochemical analyses, revealing that compact hydrophobic peptides are optimal binders.

Cryo-EM structure of an atypical proton-coupled peptide transporter: Di- and tripeptide permease C

This study determines the cryo-EM structure of DtpC, an atypical proton-coupled peptide transporter, revealing structural insights into its ligand selectivity.

Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes

The paper presents cryo-EM structures of human PepT1 and PepT2 to elucidate their transport mechanisms and provide insights for drug design.

N-terminal phosphorylation regulates the activity of Glycogen Synthase Kinase 3 from Plasmodium falciparum

This study identifies N-terminal phosphorylation sites in PfGSK3 that regulate its activity through conformational changes, offering insights into malarial parasite biology.

Identification of novel inner membrane complex and apical annuli proteins of the malaria parasite Plasmodium falciparum

This study identifies new IMC and apical annuli proteins in Plasmodium falciparum using BioID proteomics and validates their localization.

The conformational distribution of a major facilitator superfamily peptide transporter is modulated by the membrane composition

This study shows that the conformational states of the bacterial peptide transporter DtpA change with membrane lipid composition, revealing new conformations in specific lipid environments.