Hepatitis C Virus Protease Inhibitors Show Differential Efficacy and Interactions with Remdesivir for Treatment of SARS-CoV-2 in Vitro
K. A. Gammeltoft, Y. Zhou, A. Galli, A. Offersgaard, L. V. Pham, U. Fahnoe, S. Feng, S. Ramirez, J. Bukh, J. M. Gottwein
This study evaluates the efficacy of HCV protease inhibitors against SARS-CoV-2 and their interactions with remdesivir, finding simeprevir shows synergism and is the most promising for future antiviral treatments.
bioRxiv · Dec 2, 2020Microbiology