Y. Zhou

Graph-based modeling of multiparametric MRI deciphers molecular states of high-grade glioma invasion with prognostic implications

This paper uses graph-based modeling of multiparametric MRI to identify molecular states in high-grade glioma and shows their prognostic significance.

PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

This study identifies PA28γ's role in promoting oral squamous cell carcinoma progression by enhancing mitochondrial function through interaction with C1QBP.

Non-Invasive Quality Control of Organoid Cultures Using Mesofluidic CSTR Bioreactors and High-Content Imaging

This paper develops a mesofluidic bioreactor platform with high-content imaging for non-invasive quality control of brain organoids, improving their development and reducing cell death.

γ-aminobutyric acid receptor B signaling drives glioblastoma in females in an immune-dependent manner

This study shows GABA receptor B signaling promotes GBM growth in females through immune mechanisms, with sex-specific effects on survival and treatment outcomes.

Targeting NOTCH2-JAG1 juxtacrine signaling reverses macrophage-mediated tumor resistance to taxol

This study identifies NOTCH2-JAG1 juxtacrine signaling as a target to reverse macrophage-mediated taxane resistance in ovarian cancer by sensitizing tumors to paclitaxel.

An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hosts

This paper identifies a PB2-627V mutation in avian influenza viruses that enhances pandemic potential by overcoming host restriction through ANP32A proteins in both avian and mammalian hosts.

A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia

This study identifies an enhancer of Ctnnb1 that regulates Wnt signaling dosage, maintaining intestinal homeostasis and suppressing colorectal cancer.

Towards routine proteome profiling of FFPE tissue: Insights from a 1,200 case pan-cancer study

The paper profiles proteomes from 1,220 FFPE tumors across six cancers, identifies a new normalization method, and reports a comprehensive pan-cancer proteome resource.

A vacuolar invertase gene SlVI modulates sugar metabolism and postharvest fruit quality and resistance in tomato

This study investigates the role of the tomato vacuolar invertase gene SlVI in sugar metabolism, fruit quality, and postharvest resistance, finding that its knockout increases sucrose content, firmness, and resistance to Botrytis cinerea.

O-Glycosylated RNA Identification and Site-specific Prediction by Solid-phase Chemoenzymatic TnORNA method and PONglyRNA tool

This paper identifies and predicts O-glycosylated RNA using a chemoenzymatic method and a computational tool, revealing their role in pancreatic cancer progression.

Inhibitor of cardiolipin biosynthesis-related enzyme MoGep4 confers broad-spectrum anti-fungal activity

The paper identifies MoGep4 as a key enzyme in cardiolipin biosynthesis in M. oryzae, showing that its inhibitor AXD has broad-spectrum antifungal activity against plant pathogens.

Occurrence, risk assessment of antibiotics and antimicrobial resistance in Escherichia coli in typical rivers of Sichuan

This study assesses antibiotic and antimicrobial resistance in Escherichia coli from Sichuan rivers, finding high contamination and resistance rates, with specific antibiotics linked to ecological risk.

Biochemical characterization of extended-spectrum β-lactamases from Akkermansia genus

The paper characterizes β-lactamases from Akkermansia species, showing they exhibit extended-spectrum activity and lack transferable resistance genes.

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly

This study identifies CLCC1 as a regulator of hepatic neutral lipid flux and nuclear pore complex assembly through CRISPR screens and functional analyses.

mTORC2-mediated cell-cell interactions promote BMP4-induced WNT activation and mesoderm differentiation

This study shows mTORC2 is required for BMP4-induced WNT activation and mesoderm differentiation through cell-cell interactions in hESCs.

Multi-step engineered adeno-associated virus enables whole-brain mRNA delivery

This paper develops a system to package mRNAs into AAVs, enabling efficient whole-brain mRNA delivery in mice.

Muscone-specific olfactory protein reveals the putative scent-marking pheromone in the Sunda pangolin (Manis javanica)

This study identifies muscone as a potential male-specific scent-marking pheromone in Sunda pangolins through functional expression of odorant-binding proteins and behavioral assays.

Horizontally acquired CSP genes contribute to wheat adaptation and improvement

This study identifies horizontally acquired CSP genes in wheat that enhance drought tolerance and photosynthetic efficiency, contributing to wheat adaptation and improvement.

Aberrant TNF signaling in pancreatic lymph nodes of patients with Type 1 Diabetes

This study identifies heightened TNF pathway activity and chromatin remodeling in pancreatic lymph node CD4+ T cells from T1D patients, supporting the use of TNF inhibitors in clinical trials.

Single-nucleus transcriptomics reveal the cytological mechanism of conjugated linoleic acids in regulating intramuscular fat deposition

This study uses snRNA-seq in pigs to reveal CLAs promote fat infiltration by altering myofiber types and adipocyte differentiation through JNK pathway inhibition.

Nanoclustering and signaling of KRAS G12C and KRAS G12D respond to lipid acyl chain remodeling in an allele-specific manner

This study shows that KRAS G12C and G12D mutants respond differently to lipid acyl chain remodeling, affecting their nanoclustering and signaling activities.

2D Label-free Prediction of Multiple Organelles Across Different Transmitted-light Microscopy Images with Bag-of-Experts

This paper introduces a 'Bag-of-Experts' model for label-free prediction of multiple organelles across transmitted-light microscopy images, showing generalizability across imaging conditions.

The genomic and epigenomic dynamics of hemizygous genes across crops with contrasting mating systems

This study examines hemizygous genes in 22 crop genomes, finding higher hemizygosity in clonal lineages and distinct expression and epigenetic features compared to diploid genes.

The frequency dependence of prestin-mediated fast electromotility for mammalian cochlear amplification

This study investigates how mutations in prestin affect cochlear amplification and hearing, finding that reduced prestin function leads to frequency-specific hearing loss but not complete deafness.

Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles

The paper identifies IL-1β as a factor that inhibits SARS-CoV-2-induced cell-cell fusion by promoting actin bundles, thereby restricting viral transmission.

Netrin G1 Ligand is a new stromal immunomodulator that promotes pancreatic cancer

This paper identifies NGL-1 as a stromal immunomodulator in pancreatic cancer that promotes tumor growth by modulating the tumor microenvironment through TGF-β and transcription factor pathways.

Design, synthesis and cellular characterization of a new class of IPMK kinase inhibitors

This study designs, synthesizes, and characterizes a new class of IPMK kinase inhibitors, showing reduced glioblastoma cell growth and a novel InsP5 metabolic signature.

Evolutionary analysis of paired box gene family and biological function exploration of Lr.Pax7 in lamprey (Lethenteron reissneri)

This study identifies and analyzes Pax7 in lamprey, showing its potential ancestral role and functional similarities to higher vertebrates in metabolic and developmental processes.

Validating the Target Functions and Synergistic Multi-Target, Multi-Pathway Action Mode of Compound Kushen Injection Using CRISPR/CAS

This study validates the multi-target, multi-pathway action of Compound Kushen Injection by knocking out key genes in cell lines and observing changes in CKI efficacy.

Super homotypic targeting by exosome surface engineering

This paper enhances homotypic targeting by engineering exosome surfaces with lanthanides, significantly improving cell-exosome interactions and enabling new applications in diagnostics and therapy.