Chaperone Complexes From The Endoplasmic Reticulum (ER) And The Cytosol Inhibit wt-p53 By Activation The ER To Cytosol Signaling.
S. Dabsan, G. Zur, A. Gilad, A. Igbaria
The paper identifies DNAJB12 and DNAJB14 as key regulators of ER to cytosol signaling (ERCYS) that inhibit wild-type p53 during ER stress by facilitating protein reflux.
eLife · Apr 9, 2025Peer-reviewedCell Biology