S. Bhattacharya

A conjugative plasmid exploits flagella rotation as a cue to facilitate its transfer

The paper shows that the plasmid pLS20 uses flagella rotation to trigger conjugation in Gram-positive bacteria, enabling DNA transfer in liquid environments.

Development of a highly active engineered PETase enzyme for polyester degradation

This paper develops an engineered PETase enzyme, DRK3, with improved thermal stability and PET degradation efficiency compared to existing enzymes.

Computational screening of T-muurolol for an alternative antibacterial solution against Staphylococcus aureus infections: A state-of-the-art phytochemical-based drug discovery approach

This study identifies T-muurolol as a potential antibacterial agent against Staphylococcus aureus through computational screening, showing interactions with key bacterial proteins and favorable pharmacological properties.

Mpox virus (MPXV) vertical transmission and fetal demise in a pregnant rhesus macaque model

This study infects pregnant rhesus macaques with clade IIb Mpox virus and finds vertical transmission to the fetus and adverse pregnancy outcomes.

LGR4 is essential for maintaining beta-cell homeostasis through suppression of RANK

This study shows LGR4 maintains beta-cell health by suppressing RANK, with effects observed in both in vitro and mouse models under stress and aging.

Transit amplifying cells balance growth and differentiation in above-ground meristems

The paper identifies transit amplifying cells in maize meristems using spatial transcriptomics and shows their growth and differentiation are independently controlled.

Achieving Resilience in Aging: How Mitochondrial Modulation Drives Age-associated Fluconazole Tolerance in Cryptococcus neoformans

This study identifies mitochondrial metabolic changes in old Cryptococcus neoformans cells that drive fluconazole tolerance through increased ergosterol synthesis and ABC transporter upregulation.

Heterologous Prime-Boost with Immunologically Orthogonal Protein Nanoparticles for Peptide Immunofocusing

This paper develops a vaccine strategy using immunologically orthogonal protein nanoparticles to focus antibody responses on a specific SARS-CoV-2 RBD epitope.

Multiplexed in situ hybridization reveals distinct lineage identities for major and minor vein initiation during maize leaf development

This study uses multiplexed in situ hybridization to show distinct lineage identities for major and minor vein initiation in maize leaves, suggesting both lineage- and position-based mechanisms in venation patterning.

THE WIP6 TRANSCRIPTION FACTOR TOO MANY LATERALS SPECIFIES VEIN TYPE IN C4 AND C3 GRASS LEAVES

This study identifies the WIP6 transcription factor TML as specifying vein rank in maize and rice, with implications for C4 photosynthesis engineering in rice.

Extremely oligotrophic and complex carbon degrading microaerobic bacteria from Arabian Sea oxygen minimum zone sediments

The paper isolates and characterizes aerobic bacteria from Arabian Sea sediments, showing their ability to degrade complex organic matter under low oxygen conditions and maintain populations in oligotrophic environments.

Bayesian network models identify co-operative GPCR:G protein interactions that contribute to G protein coupling

This study uses Bayesian network modeling to identify cooperative GPCR:G protein interactions and their allosteric effects, revealing subnetworks that contribute to G protein coupling selectivity.

Potential use of Sodium Butyrate (SB) as an anti-virulence agent against Vibrio cholerae targeting ToxT virulence protein.

This paper shows sodium butyrate suppresses virulence in Vibrio cholerae by inhibiting ToxT-DNA binding and reducing toxin production, suggesting it as an anti-virulence agent.

A culture-based approach to study ecological interactions among the microbial species of the human scalp.

This study develops an in vitro model to examine ecological interactions among three scalp microbiota species, finding that S. epidermidis suppresses others, while C. acnes exploits M. restricta.

Oligo-PROTAC strategy for cell-selective and targeted degradation of activated STAT3

This paper develops a PROTAC-based strategy to selectively degrade activated STAT3 in specific cell types, showing efficacy in reducing STAT3 levels and tumor growth in lymphoma models.

Macrophage-specific lipid nanoparticle therapy blocks the lungs mechanosensitive immunity due to macrophage-epithelial interactions

The paper shows that macrophage-specific lipid nanoparticle therapy blocks lung mechanosensitive immunity by inhibiting Ca2+ responses and TNF secretion in alveolar macrophages.

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis

Dose-dependent progression of multiple low dose streptozotocin-induced diabetes in mice

This study compares the effects of two low-dose streptozotocin regimens in mice, showing distinct glucose tolerance, beta cell function, and transcriptional changes.

Analysis of Differential Gene Expression and Core Canonical Pathways involved in the Epithelial to Mesenchymal Transition of Triple Negative Breast Cancer Cells by Ingenuity Pathway Analysis.

The paper analyzes differential gene expression and core canonical pathways in TNBC cells undergoing EMT using RNA sequencing and IPA, identifying key pathways like Sirtuin signaling and Oxidative Phosphorylation.

E-Protein Protonation Titration-induced Single Particle Chemical Force Spectroscopy for Microscopic Understanding and pI Estimation of Infectious DENV

The paper uses chemical force spectroscopy to measure the surface charge dynamics and estimate the isoelectric point of DENV-2 and DENV-4, showing consistency between experimental and theoretical results.

Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity

This study identifies differential CpG methylation at the Nnat gene as a mechanism establishing beta cell heterogeneity during development and its potential role in diabetes.

Serial Capture Affinity Purification and Integrated Structural Modeling of the H3K4me3 Binding and DNA Damage Related WDR76:SPIN1 Complex

The paper uses SCAP to isolate the WDR76:SPIN1 complex, identifies H3K4me3 binding, and shows its role in DNA damage response through structural modeling and interaction network analysis.

Label-free digital holotomography reveals ibuprofen-induced morphological changes to red blood cells

This paper uses digital holotomography to monitor ibuprofen-induced morphological changes in red blood cells, showing dose-dependent effects and confirming structural disruption at high concentrations.

Arsenic induced alteration of neuroregulatory gene expression in Macrobrachium lamarrei: a neurotoxicological approach to grooming behaviour

This study examines how arsenic trioxide affects neuroregulatory gene expression and induces autism-like behaviors in the freshwater prawn Macrobrachium lamarrei.

Reprograming human fibroblasts into Sertoli cells: a tool for personalized medicine

This paper reprograms human fibroblasts into Sertoli cells to improve diagnosis of Disorders of Sex Development by creating a model that mimics embryonic gonadal development.

Strategic in vitro bioaugmentation of indigenous Actinobacteria isolated from east Kolkata wetlands (Ramsar site) to degrade highly toxic waste engine oil in free and emulsified state

This study shows that Gordonia terrae DSM 43249 can degrade waste engine oil more effectively in microemulsions than in free or coarse emulsions.

Glycyrrhizin, an inhibitor of HMGB1 induces autolysosomal degradation function and inhibits H. pylori infection

This study shows glycyrrhizin, an HMGB1 inhibitor, restores lysosomal function and reduces H. pylori infection in gastric cells and mice.

Dose-dependent disruption of hepatic zonation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice: integration of single-nuclei RNA sequencing and spatial transcriptomics.

This study uses single-nuclei RNA sequencing and spatial transcriptomics to show TCDD disrupts hepatic zonation in mice, leading to fat accumulation and inflammation.

A dual role for CRTH2 in acute lung injury

This study investigates CRTH2's role in acute lung injury, finding it promotes neutrophil survival but suppresses neutrophilic inflammation via IL-4.

Impact of the aryl hydrocarbon receptor on Aurora A kinase and the G2/M phase pathway in hematopoietic stem and progenitor cells

This study investigates how the aryl hydrocarbon receptor (AHR) regulates gene expression and cell cycle progression in hematopoietic stem and progenitor cells (HSPCs) through transcriptomic and flow cytometric analyses.